Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-04-04
2006-04-04
Ketter, James (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S032000, C435S254210, C536S024100
Reexamination Certificate
active
07022481
ABSTRACT:
The present invention relates to methods of using nucleotide sequences from the promoter region of at least one of sevenS. cerevisiaegenes whose expression is an indicator of the inhibition or modulation of the glucan synthase pathway inS. cerevisiae.This invention envisions using at least one target polynucleotide sequence, each target polynucleotide sequence being operably linked to the promoter region of one of the seven glucan synthase pathway reporter genes, to screen chemical libraries and natural products for compounds which can be used as antifungal agents for use against a variety of fungal pathogens. This invention also envisions using the methods of the invention to assay the efficacy of and/or specificity of antifungal agents, and/or to monitor the activity of the glucan synthase pathway.
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Schen
Ketter James
Rosetta Inpharmatics LLC
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