Methods of using G-CSF analog compositions

Details Methods of using G-CSF analog compositions Methods of using G-CSF analog compositions

2008-07-22

2008-07-22

Spector, Lorraine (Department: 1647)

Drug, bio-affecting and body treating compositions

Lymphokine

C435S069500, C530S399000

Reexamination Certificate

active

11047064

ABSTRACT:
The present invention relates to granulocyte colony stimulating factor (“G-CSF”) analog polypeptide compositions, related nucleic acids, expression constructs, host cells, and processes for recombinant production of the present G-CSF analogs. The concept detailed herein involves novel mutants of G-CSF, using single substitutions to amino acids, which were rationally chosen to affect the cellular trafficking of G-CSF and/or G-CSFR. In addition, pharmaceutical compositions, and methods of use are provided.

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