Methods of using Fc-cytokine fusion proteins

Details Methods of using Fc-cytokine fusion proteins Methods of using Fc-cytokine fusion proteins

2009-03-25

2011-10-25

Canella, Karen (Department: 1643)

Drug, bio-affecting and body treating compositions

Lymphokine

C424S085200, C424S085400, C424S278100, C514S003100

Reexamination Certificate

active

08043608

ABSTRACT:
Disclosed herein are methods and compositions for enhancing the immunogenicity of a preselected protein or peptide antigen in a mammal. Immunogenicity is enhanced by fusing the preselected antigen to an immunoglobulin heavy chain constant region to produce an Fc-antigen fusion protein. The Fc-antigen fusion proteins bind Fc receptors on the surface of antigen presenting cells, thereby targeting the antigen to the antigen presenting cells in the mammal. In addition, disclosed is a family of adjuvants, for example, an Fc-adjuvant fusion protein, for use in combination with the Fc-antigen fusion proteins to enhance or modulate a particular immune response against the preselected antigen.

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