Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-09-30
1997-06-24
Davenport, Avis M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530329, A61K 3800, C07K 500, C07K 700
Patent
active
056417527
ABSTRACT:
Novel antagonists of endothelin are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, metabolic, endocrinological, neurological disorders, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, Raynaud's disease, percutaneous transluminal coronary angioplasty or restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, ischemic bowel disease, and diabetes.
REFERENCES:
PCT International Search Report for Corresponding PCT Application--PCT/US 93/12377 Which Was Filed Dec. 17, 1993.
Chemical Abstracts, vol. 117, No. 13, Sep. 28, 1992, W.L. Cody, et al., J. Med. Chem. 1992, 35 (17), 3301-3303.
G.R. Pettit, "Synthetic Peptides", 1970, Van Nostrand Reinhold Company, p. 149.
Rovero, P., et al., British Journal of Pharmacology 101, pp. 232-234.
Doherty, A. M., et al., Abstract, Second International Conference on Endothelin, Dec. 9, 1990.
J. of Cardiovascular Pharmacology 17 (Suppl. 7) S59-S61, 1991, A. M. Doherty, et al. "Structure-Activity Studies of the C-Terminal Region of the Endothelins and the Sarafotoxins".
PCT International Search Report for Corresponding PCT Application No. PCT/US 92/03408 Filed Apr. 24, 1992.
Biochemical & Biophysical Research Comm., vol. 163, No. 1, Aug. 30, 1989, K. Nakajima, pp. 424-429.
1992 FASEB Meeting, Anaheim California, Apr. 5-9, 1992, 390, D.M. LaDouceur, et al.
Cody Wayne Livingston
DePue Patricia
Doherty Annette Marian
He John Xiaoqiang
Taylor Michael Douglas
Davenport Avis M.
Tinney Francis J.
Warner-Lambert & Company
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