Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-02
1999-04-06
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 435 72, G01N 3350
Patent
active
058916520
ABSTRACT:
Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.
REFERENCES:
patent: 5155027 (1992-10-01), Sledziewski et al.
Anderson et al., "Binding of SH2 domains of phospolipase C.gamma.1, GAP, and Src to activated growth factor receptors", Science 250, 979-982 (1990).
Bazan et al., "Structural and functional model of the platelet drived growth factor receptor extracellular domain", J. Cell. Biochem. 12, 98 (1988).
Bell et al., "Effect of platelet facators on migration of cultured bovine aortic endothelial and smooth muscle cells", Circulation Research 65, 1057-1065 (1989).
Bishayee et al., "Ligand-induced dimerization of the platelet-derived growth factor receptor", J. Biol. Chem. 264, 1169-11705 (1989).
Claesson-Welsh et al., "cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules", Mol. Cell. Biol. 8, 3476-3486 (1988).
Claesson-Welsh et al., "cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor", Proc. Natl. Acad. Sci. USA 86, 4917-4921 (1989).
Coughlin et al., "Role of phsophatidylinositol kinase in PDGF receptor signal tranduction", Science 243, 1191-1194 (1989).
Daniel et al., "Purification of the platelet-derived growth factor receptor by using an anti-phosphotyrosine antibody", Proc. Natl. Acad. Sci. USA 82, 2684-2687 (1985).
Daniel et al., "Biosynthetic and glycosylation studies of cell surface platelet-derived growth factor receptors", Biol. Chem. 262,9778-9784 (1987).
Escobedo et al., "A common PDGF receptor is activated by homodimeric A and B forms of PDGF", Science 240, 1532-1534 (1988).
Escobedo et al., "Platelet-derived growth factor receptors expressed by cDNA transfection couple to a diverse group of cellular responses associated with cell proliferation", J. Biol. Chem. 263, 1482-1487 (1988).
Escobedo et al., "Role of tyrosine kinase and membrane-spanning domains in signal transduction by the platelet-derived growth factor receptor", Mol. Cell. Biol. 8, 5126-5131 (1988).
Escobedo et al., "A PDGF receptor domain essential for mitgoensis but not for many other responses to PDGF", Nature 335, 85-87 (1988).
Fantl et al., "Mutations of the platelet-derived growth factor receptor that cause a loss of ligand-induced conformational change, subtle changes in kinase activity and impaired ability to stimulate DNS synthesis", Mol. Cell. Biol. 9, 4473-4478 (1989).
Felder et al., "Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body", Cell 61, 623-634 (1990).
Glenn et al., "Platelet-derived growth factor", J. Biol. Chem. 257, 5172-5176 (1982).
Gronwald et al. "Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: Evidence for more than one receptor class", Proc. Natl. Acad. Sci. USA 85, 3435-3439 (1988).
Hart et al., "Synthesis, phosphorylation, and degradation of multiple forms of the platelet-derived growth factor receptor studied using a monoclonal antibody", J. Biol. Chem. 262, 10780-10785 (1987).
Hart et al., "Two classes of PDGF receptors recognize different isoforms of PDGF", Science 240, 1529-1531 (1988).
Hart et al. "Expression of secreted human immunogolobulin/PDGF-receptor fusion proteins which demonstrate high affinity ligand binding", Miami Winter Cancer Syposium (1989).
Haynes et al., "Constitutive, long-term production of human interferons by hamster cells containing multiple copies of a cloned interferons gene", Nucl. Acids Res. 11, 687-706 (1983).
Heidaran et al., "Chimeric .alpha.-and .beta.-platelet derived growth factor (PDGF) receptors define three immunoglobulin-like domains of the .alpha.-PDGF receptor that determine PDGF-AA binding specificity", J. Biol. Chem. 265, 18741-18744 (1990).
Heldin et al., "Interacation of platelet-derived growth factor with its fibroblast receptor", J. Biol. Chem. 257, 4216-4221 (1982).
Heldin et al., "Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types", EMBO J. 7, 1387-1393 (1988).
Heldin et al., "Dimerization of B-type platelet-derived growth factor receptors occurs after ligand binding and is closely associated with receptor kinase activation", J. Biol. Chem. 264, 8905-8912 (1989).
Kaplan et al., "PDGF .beta.-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a singaling complex", Cell 61, 125-133 (1990).
Kazlauskas et al., "Different effects of homo- and heterodimers of platelet-derived growth factor A and B chains on human and mouse fibroblasts", EMBO J. 7, 3727-3735 (1988).
Keating et al., "Processing of the platelet-derived growth factor receptor", J. Biol. Chem. 262, 7932-7937 (1987).
Keating et al., "Ligand activation cause a phosphorylation-dependent change in platelet-derived growth factor receptor conformation", J. Biol. Chem. 263, 12805-12808 (1988).
Keating et al., "Autocrine stimulation of intracellular PDGF receptor in v-sis-transformed cells", Science 239, 914-916 (1988).
Keating et al., "Platelet-derived growth factor receptor inducibility is acquired immediately after translation and does not require glycosylation", J. Biol. Chem. 264, 9129-9132 (1989).
Kimball et al., "Epidermal growth factor (EGF) binding to membranes immobilized in microtiter wells and estimation of EGF-related transforming growth factor activity", Biochem. Biophys. Acta 771, 82-88 (1984).
Kornbluth et al., "Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries", Mol. Cell. Biol. 8, 5541-5544 (1988).
Kypta et al., "Association between the PDGF receptor and membrane of the src family of tyrosine kinases", Cell 62, 401-492 (1990).
Marx, "Oncogenes evoke new cancer therapies", Science 249, 1376-1378 (1990).
Matsui et al., "Isolation of a novel receptor cDNA establishes the existance of two PDGF receptor genes", Scienece 243, 800-803 (1989).
Moran et al., "Src homology region 2 domains direct protein-protein interactions in signal transduction", Proc. Natl. Acad. Sci. USA 87, 8622-8626 (1990).
Morrison et al., "Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF .beta.-receptor", Cell 58, 649-657 (1989).
Morrison et al., "Platelet-derived growth factor (PDGF)-dependent associated of phospholipase C- with the PDGF receptor signaling complex", Mol. Cell. Biol. 10, 2359-2366 (1990).
Nishibe et al., "Increase of the catalytic activity of phospholipase c-.gamma.1 by tyrosine phosphorylation", Science 250, 1253-1256 (1990).
Nister et al., "A glioma-derived PDGF A chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets", Cell 52, 791-799 (1988).
Orchansky et al., "Expression and characterization of the extracytoplasmic portion of the mouse platelet derived growth factor receptor", J. Cell. Biochem. 12, 110 (1988).
Orchansky et al., "Phosphatidylinositol linkage of a truncated form of the platelet-derived growth factor receptor", J. Biol. Chem. 263, 15159-151565 (1988).
Peralta et al., "Primary structure and biochemical properties of an M.sub.2 muscarinic receptor", Science 257, 600-605 (1987).
Qiu et al., "Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C terminus" EMBO J. 7, 1003-1011 (1988).
Reid et al., "Two forms of the basic fibroblast growth factor receptor-like mRNA are expressed in the developing in the developing mouse brain", Proc. Natl. Acad. Sci. USA 87, 1596-1600 (1990).
Ronnstrand et al., "Purification of the receptor for platelet-derived growth factor from porcine uterus", J. Biol.
Escobedo Jaime A.
Fretto Larry J.
Giese Neill A.
Tomlinson James E.
Williams Lewis Thomas
Gucker Stephen
Hutzell Paula K.
Morgan Lorie Ann
The Regents of the University of California
LandOfFree
Methods of using domains of extracellular region of human platel does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of using domains of extracellular region of human platel, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of using domains of extracellular region of human platel will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1370193