Methods of using diaminopyrimidine P2X 3 and P2X 2/3...

Details Methods of using diaminopyrimidine P2X 3 and P2X 2/3... Methods of using diaminopyrimidine P2X 3 and P2X 2/3...

2011-08-30

2011-08-30

Anderson, James (Department: 1629)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S269000, C514S826000

Reexamination Certificate

active

08008313

ABSTRACT:
Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3and/or a P2X2/3receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I):or a pharmaceutically acceptable salt thereof,wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7and R8are as defined herein.

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MedlinePlus, “Asthma”, MedlinePlus, May 21, 2009, downloaded from “http://www.nlm.nih.gov/medlineplus/ency/article/000141.htm” on Oct. 22, 2009, pp. 1-4 of 4.
Galligan, J. J. “Enteric P2X Receptors as Potential Targets for Drug Treatment of the Irritable Bowel Syndrome,”British J. Pharmacology, 2004 vol. 141 (8), p. 1294-1302.

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