Methods of using chemiluminescent 1,2-dioxetanes

Details Methods of using chemiluminescent 1,2-dioxetanes Methods of using chemiluminescent 1,2-dioxetanes

1988-06-30

1990-06-05

Lee, Mary C.

Compositions

Chemiluminescent

435 4, 435 5, 435 7, 436537, C07D30504, C07D40704

Patent

active

049312235

ABSTRACT:
Processes are disclosed in which light of different wavelengths is simultaneously released from two or more enzymatically decomposable chemiluminescent 1,2-dioxetane compounds, said compounds being configured, by means of the inclusion of a different light emitting fluorophore in each of them, to each emit light of said different wavelengths, by decomposing each of said compounds by means of a different enzyme. Such processes can be used in multi-channel assays--immunoassays, chemical assays and nucleic acid probe assays--to detect the presence or determine the concentration of chemical or biological substances, and in multi-channel chemical/physical probe procedures for studying the microstructures of macromolecules.

REFERENCES:
patent: 3720622 (1973-03-01), Bollyky
patent: 4663278 (1987-05-01), DiNello
Zaklika, "Mechanisms . . . ", Photochem. Photobiol. 30, 35 (1979).
Zaklika, "Mechanisms . . . ", J. Amer. Chem. Soc. 100, 4916 (1978).
Schaap, "Chemiluminescence . . . ", J. Amer. Chem. Soc., 104, 3504 (1982).
Schaap, "Substituted Effects . . . ", Tetrahedron Lett. 2943 (1982).
Adam et al., "Thermal Stability . . . ", Chem. Ber., 116, 839 (1983).

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