Methods of using CD8 binding domain peptides

Details Methods of using CD8 binding domain peptides Methods of using CD8 binding domain peptides

1994-07-22

1997-04-15

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 514 16, 435 71, 435377, 530300, 530327, 530328, 530329, A61K 3800, A61K 3802, C07K 500, C07K 700

Patent

active

056209568

ABSTRACT:
The present invention provides compositions comprising a peptide having between about 7 and about 20 amino acid residues, the peptide being capable of binding a CD8 molecule on a cytolytic T lymphocyte (CTL) precursor and inhibiting differentiation of the CTL precursor to a mature CTL. The peptides have amino acid sequences substantially homologous to a sequence in an .alpha.3 domain of a human Class I MHC molecule. The sequence from the .alpha.3 domain is preferably between residue 220 and residue 235. The peptides typically comprise the sequences DQTQDTE (SEQ. ID No. 1) or EDQTQDTELVETRP (SEQ. ID No. 2).

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K onig et al., Nature, vol. 356, pp. 796-798, 30 Apr. 1992.
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Potter et al., Nature, vol. 357, pp. 73-75, 5 Jan. 1989.
Connolly et al., P.N.A.S., pp. 2137-2141, Mar. 1990.

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