Methods of using carboxylic acid esters to increase fetal-hemogl

Details Methods of using carboxylic acid esters to increase fetal-hemogl Methods of using carboxylic acid esters to increase fetal-hemogl

1994-03-07

1996-10-29

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514512, 514533, 514548, 514815, 514895, A61K 31225

Patent

active

055696759

ABSTRACT:
This invention relates to novel methods of increasing the level of fetal hemoglobin (HbF) in a subject and methods of treating, preventing or ameliorating .beta.-globin or other HbF-related disorders by increasing the level of HbF in a subject in need of such treatment comprising administering one or more compounds of the Formulae (I), (II), or (III):

REFERENCES:
patent: 4822821 (1989-04-01), Perrine
patent: 5025029 (1991-06-01), Perrine
patent: 5200553 (1993-04-01), Nudelman et al.
patent: 5216004 (1993-06-01), Perrine
Charache et al., 1993, PNAS, 80:4842-4846 Treatment of sickel cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the .mu.-.delta.-.beta.globin gene complex.
Charache et al., 1987, Blood, 69:109-116 Hydroxyurea-Induced Augmentation of Fetal Hemoglobin Production in Patients with Sickle Cell Anemia.
Perrine and Faller, 1993, Experiencia, 49:133-137 Butryate-induced reactivation of the fetal globin genes: A molecular treatment for the .beta.-hemoglobinopathies.
Dover et al., 1992, New Eng. J. Med., 327:569-570 Increased Fetal Hemoglobin in Patients Receiving Sodium 4-Phenylbutyrate.
Fibach et al., 1993, Blood, 82:1-7 Enhanced Fetal Hemoglobin Production by Phenylacetate and 4-Phenylbutyrate in Erythroid Precursors Derived From Normal Donors and Patients with Sickle Cell Anemia and .beta.-Thalassemia.

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