Methods of using aminothiols to promote hematopoietic progenitor

Details Methods of using aminothiols to promote hematopoietic progenitor Methods of using aminothiols to promote hematopoietic progenitor

1998-03-24

1999-05-25

Cook, Rebecca

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514665, A61K 3166, A61K 3113

Patent

active

059069848

ABSTRACT:
The present invention relates to methods of stimulating he growth of hematopoietic progenitor cells. In particular, it relates to the use of thiols and related compounds in stimulating the growth of hematopoietic progenitor cells in vitro and in vivo. Furthermore, the present invention relates to methods of using these compounds for the treatment of marrow failure states and immunodeficient conditions, including but not limited to myelodysplastic syndromes and acquired immunodeficiency syndrome.

REFERENCES:
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Patchen et al, Seminars in Oncology, vol. 21 (5) Suppl. 11, 26-32, 1994.
Ash et al., "Studies of Human Pluripotential Hemopoietic Stem Cells (CFU-M) In Vitro," Blood, 58(2), 309-316 (1981).
Douay et al., "Amifostine (WR-2721) protects normal hematopoietic stem cells against cyclophosphamide derivatives' toxicity without compromising their antileukemic effects," Chemical Abstracts, 123:306175 (1995).
Hankins et al., "Effects of Sulfhydryl Compounds on Friend Virus-infected Spleen Cells in Vitro," J. Biol. Chem., 254(13), 5701-5707 (1979).
Helgestad et al., "Vitamin C and Thiol Reagents Promote the In Vitro Growth of Murine Granulocyte/Macrophage Progenitor Cells by Neutralizing Endogenous Inhibitor(s)," Blut, 52, 1-8 (1986).
Patchen et al., "Granulocyte Colony-Stimulating Factor and Amifostine (Ethyol) Synergize to Enhance Hemopoietic Reconstitution and Increase Survival in Irradiated Animals," Seminars in Oncology, 21(5), Suppl. 11, 26-32 (1994).
Patchen et al., "Postirradiation Glucan Administration Enhances the Radioprotective Effects of WR-2721," Radiation Research, 117, 59-69 (1989).
Toohey, "Sulfhydryl Dependence in Primary Explant Hematopoietic Cells. Inhibition of Growth In Vitro with Vitamin B.sub.12 Compounds," Proc. Nat. Acad. Sci. USA, 72(1), 73-77 (1975).

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