Methods of using ajoene for the treatment of tumors

Details Methods of using ajoene for the treatment of tumors Methods of using ajoene for the treatment of tumors

1995-05-19

1999-08-03

Jarvis, William R. A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Sulfur, selenium or tellurium compound

514708, A61K 31105, A61K 3110

Patent

active

059326212

ABSTRACT:
The present invention relates to the use of Ajoene to treat integrin-mediated tumors and metastasis.

REFERENCES:
patent: 4126676 (1978-11-01), Sanders
patent: 4341762 (1982-07-01), Haast
patent: 4643994 (1987-02-01), Block et al.
patent: 4665088 (1987-05-01), Apitz-Castro et al.
patent: 4876281 (1989-10-01), Yoshida et al.
patent: 5066658 (1991-11-01), Demers et al.
patent: 5093122 (1992-03-01), Kodera
patent: 5380646 (1995-01-01), Knight et al.
patent: 5464855 (1995-11-01), Capiris et al.
Sud'ina et al., 1991, Biochimica et Biophysica Acta, 1091:257-60.
Tatarintsev et al., International Conference on Molec. Biol. Aspects of Diagnostics and Therapy of AIDS, Conference poster and abstract, Jul. 2-5, 1991.
Tatarintsev et al., European Developmental Biology Congress, Conference abstract, Aug. 11-15, 1991.
Tatarintsev et al., Keystone Symposia on Molec. & Cell. Biol., Conference abstract, Feb. 1992.
Tatarintsev et al., Keystone Symposia on Molec. & Cell. Biol., Conference abstract, Mar. 1992.
Karamov et al., Keystone Symposia on Molec. & Cell. Biol., Conference Abstract, Apr. 4, 1992.
Tatarintsev et al., Keystone Symposia on Molec. & Cell. Biol., Conference abstract, Apr. 4, 1992.
Tatarintsev et al., VIII Int'l Conf. on AIDS, Conference abstract, Jul. 19-24, 1992.
Apitz-Castro et al., 1983, Thrombosis Research, 32(2):155-69.
Block et al., 1984, J. Am. Chem. Soc., 106(26):8295-96.
Block et al., 1986, J. Am. Chem. Soc., 108(22):7045-55.
Apitz-Castro et al., 1986, Thrombosis Research, 42:303-11.
Apitz-Castro et al., 1986, Biochemical and Biophysical Research Communications, 141(1):145-50.
Jain et al., 1987, TIBS, 12(7):252-54.
Jamaluddin et al., 1988, Biochemical and Biophysical Research Communications, 153(1):479-86.
Apitz-Castro et al., 1988, Drug Research, 38(7):901-04.
Debouzy et al., 1989, European Biophysics Journal, 17:211-16.
Rendu et al., 1989, Biochemical Pharmacology, 38(8):1321-28.
Apitz-Castro et al., 1991, Biochemica et Biophysica Acta, 1094(3):269-80.
Apitz-Castro et al., 1991, Thrombosis and Haemotology, 65(6):Abstract No. 1380 at p. 1079.
Apitz-Castro et al., 1991, Thrombosis and Haemotology, 65(6):Abstract No. 1603 at p. 1141.
Srivestava, 4th Erfurt Conference on Platelets, Jun. 22-27, 1992, p. 19.
Ali et al., Book of Abstracts, VIII Int'l Conf. on Prostaglandins & Related Compounds, Montreal, Jul. 1992, abstract No. 54.
Apitz-Castro et al., Platelet Membrane I, No. P1077, 1987.
Apitz-Castro et al., Platelet Pharmacology III, No. 0747, 1988.
Apitz-Castro et al., Supplementary Abstracts, No. 2021, 1990.
Belman et al., 1989, Journal of Biochemical Toxicology, 4(3):151-60.
Scharfenberg et al., 1990, Cancer Letters, 53:103-08.
Yoshida et al., 1987, Applied and Environmental Microbiology, 53(3):615-17.
San-Blas et al., 1989, Antimicrobial Agents and Chemotherapy, 33(9):1641-44.
Singh et al., 1990, Can. J. Bot., 68(6):1354-56.
Gargouri et al., 1989, Biochemica et Biophysica Acta, 1006(1):137-39.
Mohammed et al., 1986, Thrombosis Research, 44:793-806.
Mayeux et al., 1986, Prostaglandins 1, 45(3):Abstract 2936 at p. 660.
Mayeux et al., 1988, Agents and Actions, 25:182-90.
Tang et al., Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine, Chapter 11, 1991.
Mirelman et al., 1987, The Journal of Infectious Diseases, 156(1):243-44.
Shalinsky et al., 1989, Prostaglandins, 37(1):135-48.
Focke et al., 1990, FEBS Letters, 261(1):106-08.
Kourounakis et al., 1991, Research Communications in Chemical Pathology and Pharmacology, 74(2):249-52.
Liakopoulou-Kyriakides et al., 1985, Phytochemistry, 24(3):600-01.
Liakopoulou-Kyriakides, 1985, Phytochemistry, 24(7):1593-94.
Nagai, 1973, Japanese Journal of Infectious Diseases, 47:321-25.
Bordia, 1978, Athersclerosis, 30:355-60.
Esanu, 1981, Rev. Roum. Med.-Virol., 32(1):57-77.
Tsai et al., 1986, Chemical Abstracts, 104(24):No. 61572a.
Bayer et al., 1988, Planta Medica, 54(6):560 K1-6.
Block, 1985, Scientific American, 252(3):94-99.
Auger et al., 1990, Chemosphere, 21(7):837-43.
Jansen et al., 1987, Planta Medica, 53(6):559-62.
Yu et al., 1989, Journal of Food Science, 54(4):977-81.
Saito et al., 1989, Journal of the Association of Analytical Chemists, 72(6):917-20.
Ziegler et al., 1987, Pharmaceutisch Weekblad Scientific Edition, 9(4):248 (Abstract).
Mochizuki et al., 1988, Journal of Chromatography, 455:271-77.
Lancaster et al., 1989, Phytochemistry, 28(2):455-60.
Lancaster et al., 1989, Phytochemistry, 28(2):461-64.
Ziegler et al., 1989, Journal of Liquid Chromatography, 12(1 & 2):199-200.
Ziegler et al., 1989, Planta Medica, 55(4):372-78.
Nock et al., 1986, Archives of Biochemistry and Biophysics, 249(1):27-33.
Nock et al., 1987, Plant Physiology, 85(4):1079-83.
Knobloch et al., 1987, Pharmaceutisch Weekblad Scientific Edition, 9:218.
Knobloch et al., 1988, Planta Medica, 54(6):561-62, K1-9.
Jansen et al., 1989, Planta Medica, 55:434-49.
Jansen et al., 1989, Planta Medica, 55:440-45.
Nock et al., 1989, Phytochemistry, 28(3):729-31.
Won et al., 1989, Physiologia Plantarum, 77(1):87-92.
Fugita et al., 1990, Arch. of Biol. & Chem., 54(4):1077-79.
Rabinkov et al., 1991, Mechanisms of Action III, 5:1149 Abstract No. 4509.
Gmelin et al., 1976, Phytochemistry, 15(11):1717-21.
Ibert et al., 1990, Planta Medica, 56(2):202-11.
Ibert et al., 1990, Planta Medica, 56(3):320-26.
Lawson et al., 1991, Planta Medica, 57(3):263-70.
Sendl et al., 1991, Planta Medica, 57(4):361-62.
Lawson et al., 1991, Planta Medica, 57(4):363-70.
Blania et al., 1991, Planta Medica, 57:(4):371-75.
Yu et al., 1989, Journal of Agric. Food Chem., 37(3):725-30.
Yu et al., 1989, Journal of Agric. Food Chem., 37(3):730-34.
Yu et al., 1989, Journal of Food Science, 54(3):632-35.
Yu et al., 1989, Journal of Chromatography, 462:137-45.
Lawson et al., 1991, Journal of Natural Products, 54(2):436-44.
Phillips et al., 1988, Blood, 71:831-43.
Barbillari et al., 1993, Proc. Natl. Acad. Sci. USA, 90:7941.
Blood et al., 1990, Biochim. Biophys. Acta, 1032:89-118.
Brake et al., 1990, J. Cell Biol., 111:1275.
Cheresh et al., 1987, J. Biol. Chem., 262:17703-17711.
Crowe et al., 1991, Mechanisms and Specificity of HIV Entry into Host Cells, 57-70.
Diegel et al., 1993, AIDS Res. Human Retrovir., 9:465.
Fecondo et al., 1993, AIDS Res. Human Retrovir., 9:733.
Fujita et al., 1992, Jpn. J. Cancer Res., 83:1317-26.
Golding et al., 1992, AIDS Res. Human Retrovir., 8:1593.
Gruber et al., 1991, AIDS Res. Human Retrovir., 7:45.
Kreis et al., 1993, Guidebook to the Extracellular Matrix and Adhesion Proteins, p. 143.
Guo et al., 1993, J. Immunol., 151:2225.
Hansen et al., 1991, Scan J. Infect. Dis., 23:31-36.
Hart et al., 1991, Cancer and Metastasis Rev., 10:115-128.
Hildreth et al., 1989, Science, 244:1075-1078.
Honn et al., 1992, Exp. Cell Res., 201:23-32.
Humphries et al., 1986, Science, 233:467-70.
Johnson et al., 1989, Proc. Natl. Acad. Sci. USA, 86:641-644.
Kalter et al., 1991, Immunol. Letters, 30:219.
Kawaguchi et al., 1992, Jpn. J. Cancer Res., 83:1304-1316.
Knudsen et al., 1988, J. Cell. Physiol., 136:471-78.
Kramer et al., 1989, Cancer Res., 49:393-402.
Kramer et al., 1991, Cancer and Metastasis Rev., 10:49-59.
Meerloo et al., 1993, J. Gen. Virol., 74:129.
Mortarini et al., 1992, Cancer Res., 52:4499-4506.
Murata et al., 1992, Jpn. J. Cancer Res., 83:1327-1333.
Nip et al., 1992, J. Clin. Invest., 90:1406-1413.
Orentas et al., 1993, AIDS Res. Human Retrovir., 9:1157.
Pantaleo et al., 1991, J. Exp. Med., 173:511-514.
Pearce-Pratt et al., 1993, Biology of Reproduction, 48:431.
Roossien et al., 1989, J. Cell Biol., 108:1979-83.
Saiki et al., 1990, Jpn. J. Cancer Res., 81:660-67.
Saiki et al., 1990, Jpn. J. Cancer Res., 81:668-75.
Saiki et al., 1990, Jpn. J. Cancer Res., 81:1003-1011.
Smole et al., 1992, FASEB J., 6:A1714.
Soszka et al., 1991, Exp. Cell Res., 196:6-12.
Springer, 1990, Nature, 346:425.
Thieblemont et al., 1993, Clin. Exp. Immunol., 92:106.
Ugen, 1988, J. Natl. Cancer Inst., 80:1461.
Valentin et al., 1990, J. Immunol., 144:934-937.
Van Muijen et al., 1991, Int. J. Cancer, 48:85-91.
Vermont-Desroches et al., 1991, Molec. Immunol., 28:1095.
V

Affiliated with

Also associated with

Rating

Methods of using ajoene for the treatment of tumors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of using ajoene for the treatment of tumors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of using ajoene for the treatment of tumors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-849948