Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Sulfur – selenium or tellurium compound
Patent
1996-01-11
1999-11-09
Jarvis, William R. A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Sulfur, selenium or tellurium compound
514706, 514708, A61K 31105, A61K 31095
Patent
active
059816023
ABSTRACT:
The present invention relates to the use of ajoene for inhibiting integrin-mediated cell-cell fusion. Specific types of cell-cell fusion are giant multinucleated cell formation, syneytia formation, and osteoclast formation.
REFERENCES:
patent: 4126676 (1978-11-01), Sanders
patent: 4341762 (1982-07-01), Haast
patent: 4643994 (1987-02-01), Block et al.
patent: 4665088 (1987-05-01), Apitz-Castro et al.
patent: 4876281 (1989-10-01), Yoshida et al.
patent: 5066658 (1991-11-01), Demers et al.
patent: 5093122 (1992-03-01), Kodera
patent: 5380646 (1995-01-01), Knight et al.
patent: 5464855 (1995-11-01), Capiris et al.
Ramos et al., 1991, Invasion Metastasis, 11:125-138.
Schreiner et al., 1991, Cancer Research, 51:1738-1740.
Van Waes et al., 1992, Molecular Biology And Genetics, 25(5):1117-1139.
Wake et al., 1995, Blood, 86(6):2257-2267.
Witjes et al., 1995, Carcinogenesis, 16(11)2825-2832.
Zutter et al., 1990, American Journal of Pathology, 137(4):863-870.
Meyers, Adv. Vet. Sci. Comp. Med., 30:131-165 (1985).
Pollard et al., Monogr. Neural Sci., 7:106-116 (1980).
Zhuang et al., Biochem. Biophys. Res. Commun., 159(1):236-241 (1989).
Rendu et al, Chemical Abstracts, vol. 111, abstract No. 464, 1989.
Belman et al., Chem. Abstracts, 112:91227 (1990).
Dausch et al., Chem. Abstracts, 113, 184048c, (1990).
Delaha et al., Chem. Abstracts, 102, 218177j, (1985).
Delaha et al., 1985, Antimicrob. Agents Chemother., 27(4):485-6.
Demers et al., Chem. Abstracts, 116:128198 (1992).
Douvas et al., 1991, Proc. Nat'l Acad. Sci USA, 88:6328-6332.
Lichtenstein et al., Chem. Abstracts, 104, 45756h, (1986).
Meng et al., Chem. Abstracts, 115, 43950v, (1991).
Meng et al., 1990, Nutr. Cancer, 14(3-4):207-17.
Merck Index, No. 185 (1969).
Mohr, Chem. Abstracts, 108, 54653g, (1988).
Mohr, 1987, Gordian, 87(10):195-6 and English translation.
Nakagawa et al., 1989, Chem. Abstracts, 111:146760e.
Nakagawa et al., 1989, Phytotherapy Res., 3:50-53.
Nakata et al., Chem. Abstracts, 79, 111680x (1973).
Nakata, 1973, Nippon Eiseigaku Zasshi, 27(6):538-43 and English translation.
Nishikawa et al., Chem. Abstracts, 74:30034j (1971).
Perez et al., Chem. Abstracts, 120, 182454c, (1994).
Nagai, 1973, Japanese Journal of Infectious Diseases, 47:321-25.
Bordia, 1978, Atherosclerosis, 30:355-60.
Esanu, 1981, Rev. Roum. Med.-Virol., 32(1):57-77.
Tsai et al., 1986, Chemical Abstracts, 104(24):No. 61572a.
Bayer et al., 1988, Planta Medica, 54(6):560 K1-6.
Block, 1985, Scientific American, 252(3):94-99.
Auger et al., 1990, Chemosphere, 21(7):837-43.
Jansen et al., 1987, Planta Medica, 53(6):559-62.
Yu et al., 1989, Journal of Food Science, 54(4):977-81.
Saito et al., 1989, Journal of the Association of Analytical Chemists, 72(6):917-20.
Ziegler et al., 1987, Pharmaceutisch Weekblad Scientific Edition, 9(4):248 (Abstract).
Mochizuki et al., 1988, Journal of Chromatography, 455:271-77.
Lancaster et al., 1989, Phytochemistry, 28(2):455-60.
Lancaster et al., 1989, Phytochemistry, 28(2):461-64.
Ziegler et al., 1989, Journal of Liquid Chromatography, 12(1 & 2):199-200.
Ziegler et al., 1989, Planta Medica, 55(4):372-78.
Nock et al., 1986, Archives of Biochemistry and Biophysics, 249(1):27-33.
Nock et al., 1987, Plant Physiology, 85(4):1079-83.
Knobloch et al., 1987, Pharmaceutisch Weekblad Scientific Edition, 9:218.
Knobloch et al., 1988, Planta Medica, 54(6):561-62, K1-9.
Jansen et al., 1989, Planta Medica, 55:434-49.
Jansen et al., 1989, Planta Medica, 55:440-45.
Nock et al., 1989, Phytochemistry, 28(3):729-31.
Won et al., 1989, Physiologia Plantarum, 77(1):87-92.
Fugita et al., 1990, Arch. of Biol. & Chem., 54(4):1077-1079.
Rabinkov et al., 1991, Mechanisms of Action III, 5:1149 Abstract No. 4509.
Gmelin et al., 1976, Phytochemistry, 15(11):1717-21.
Iberl et al., 1990, Planta Medica, 56(2):202-11.
Zahalka et al., 1993, J. Immunol., 150:4446-4477.
Mousa et al., 1994, Circulation, 89(1):3-12.
Nemerow et al., 1994, Trends in Cell Biology, 4:53-55.
Ohta et al., 1994, The EMBO Journal, 13(9):2044-2055.
Palmer et al., 1993, Clin. Exp. Immunol., 93:344-349.
Pantaleo et al., 1994, Current Opinion in Immunology, 6:600-604.
Paul, 1995, Science, 267:633-636.
Phillips, 1994, AIDS, 8:719-731.
Reinhardt et al., 1993, IX International Conference on AIDS, PO-A14-0285, p. 182.
Reynolds-Kohler et al, 1991, Mechanisms and Specificity of HIV Entry Into host Cells, pp. 27-44.
Rossen et al., 1989, Trans. Ass. Am. Physicians, 102:117-130.
Sato et al., 1992, Virology, 186:712-724.
Scarborough et al., 1993, The Journal of Biological Chemistry, 268(2):1058-1065.
Schuitemaker et al., 1992, Journal of Virology, 66(3):1354-1360.
J.C., 1993, Science, 260:1256.
Shebuski et al., 1990, Thrombosis and Haemostasis, 64(4):576-581.
Sheu et al., 1994, J. Lab. Clin. Med., 123(2):256-263.
Stent et al., 1994, Journal of Leukocyte Biology, 56:304-309.
Stevenson et al., 1992, AIDS Res. and Human Retrovir., 8(2):107-117.
Tabata et al., 1994, J. Immunol., 153:3256-3266.
Taichman et al., 1991, Cell Regulation, 2:347-355.
Tang et al., 1993, Int. J. Cancer, 54:338-347.
Tcheng et al., 1994, Circulation, 90(4):1757-1764.
Trikha et al., 1994, Cancer Research, 54:4993-4998.
Weeks et al., 1991, J. Cell Biol., 114:847-853.
Aboulker et al., 1993, The Lancet, 341:889-890.
Yarchoan et al., 1992, J. Enzyme Inhibition, 6:99-111.
Yarchoan et al., 1991, Blood, 78(4):859-884.
Gehlsen et al., 1992, Clin. Exp. Metastasis, 10:111-120.
Glander et al., 1993, International Journal of Andrology, 16:105-111.
Gonzalez-Scarano et al., 1992, Seminars in Virology, 3:225-234.
Gougeon et al., 1993, Science, 260:1269-1270.
Grau et al., 1991, Eur. J. Immunol., 21:2265-2267.
Guo et al., 1995, AIDS Res. and Human Retrovir., 11:1007-1013.
Hamilton et al., 1992, The New England Journal of Medicine, 326:437-443.
Hardan et al., 1993, Int. J. Cancer, 55, 1023-1028.
Harning et al., 1993, Clin. Exp. Metastasis, 11:337-342.
Haynes, 1993, Science, 260:1279-1286.
Huitinga et al., 1993, Eur. J. Immunol., 23:709-715.
Isberg et al., 1994, Trends in Microbiology, 2(1):10-14.
Ishizuka et al., 1993, Int. J. Immunopharmacol., 17(2):133-139.
Ito et al., 1992, Journal of Virology, 66(17):5999-6007.
Johnson, 1992, AIDS Clinnical Review, pp. 70-104.
Johnston, 1993, Science, 260:1286-1293.
Kavanaugh et al., 1994, Arthritis & Rheumatism, 37:992-999.
Kazazi et al., 1994, Journal of General Virology, 75:2795-2802.
Kolson et al., 1993, AIDS Res. and Human Retrovir., 9(7):677-685.
Larson et al., 1990, Immunological Reviews, 114:181-216.
Levy, 1991, Adv. Exp. Med. Biol., 300:1-15.
Li et al., 1995, Science, 268:429-431.
Locher et al., 1994, Clin. Exp. Immunol., 98:115-122.
Mitsuya et al., 1991, The FASEB Journal, 5:2369-2381.
MMWR (Morbidity and Mortality Weekly Report, 43(16):285-287, 1994.
Mohan, 1993, Drug Development Research, 29:1-17.
Mould et al., 1991, The Journal of Biological Chemistry, 266(6):3579-3585.
Acosta et al., 1994, Am. J. Hosp. Pharm., 51:2251-2267.
Allen et al., 1995, Medical Hypotheses, 45:164-168.
Altieri et al., 1988, Leukocyte Fibrinogen Receptor, pp. 1893-1900.
Arthur et al., 1992, Science, 258:1935-1938.
Asselot-Chapel et al., 1993, HIV1 Infection of Macrophages Results in Modulation of Fibronectin and .alpha.5.beta.1 Integrin Biosynthesis, IX International Conference on AIDS, PO-A12, p. 169.
Birdsall et al., 1994, Journal of Leukocyte Biology, 56:310-317.
Blobel et al., 1992, Nature, 356:248-252.
Bourinbaiar et al., 1993, Acta. Virol., 37:21-28.
Bourinbaiar et al., 1994, Cellular Immunology, 155:230-236.
Bridges et al., 1994, Antiviral Research, 25:169-175.
Butera et al., 1992, AIDS Res. and Human Retrovir., 8(6):991-995.
Butini et al., 1993, ICAM-1/2/3 Molecules Function as Counter-Receptors for LFA-1 in HIV-Mediated Syncytia Formation, IX International Conference on AIDS, PO-A14, p. 182.
Butini et al., 1994, Eur. J. Immunol., 24:2191-2195.
Carlos et al., 1990, Immunological Reviews, 114:5-28.
Chehimi et al., 1993, Journal of General Virology, 74:1277-1285.
Clapham et al., 1993, Phil. Trans. R. Soc. Long. B, 342:67-73.
Coller et al., 1989, Circulation, 80(6):1766-1774.
Collman et al., 1992, Seminars in Virology, 3:18
Davidson John B.
Tatarintsev Alexander V.
Turgiev Ali S.
Davidson John B.
Jarvis William R. A.
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