Methods of using ajoene

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Sulfur – selenium or tellurium compound

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514886, 514887, A61K 31105

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active

059488212

ABSTRACT:
The progression of infection and other pathologies produced by a viral infection may be inhibited by administering an effective dosage of Ajoene. Additionally, Ajoene has anti-tumor, anti-shock, and antiinflammation effects. In general, Ajoene may be used to treat any integrin-mediated disease or condition.

REFERENCES:
patent: 4126676 (1978-11-01), Sanders
patent: 4341762 (1982-07-01), Haast
patent: 4643994 (1987-02-01), Block et al.
patent: 4665088 (1987-05-01), Apitz-Castro et al.
patent: 4876281 (1989-10-01), Yoshida et al.
patent: 5066658 (1991-11-01), Demers et al.
patent: 5093122 (1992-03-01), Kodera
patent: 5380646 (1995-01-01), Knight et al.
patent: 5464855 (1995-11-01), Capiris et al.
Adler et al., "Sequential .sup.1 H NMR Assignments of Kistrin, a Potent Platelet Aggregation Inhibitor and Glycoprotein IIb-IIIa Antagonist", Biochemistry, vol. 31, pp. 1031-1039 (1992).
Adler et al., "Solution Structure of Kistrin, a Potent Platelet Aggregation Inhibitor and GP IIb-IIIa Antagonist," Science, vol. 253, pp. 445-448 (1991).
Adler et al., "Cysteine Pairing in the Glycoprotein IIbIIIa Antagonist Kistrin Using NMR, Chemical Analysis, and Structure Calculations," Biochemistry, vol. 32, pp. 282-289 (1993).
Au, et al., "A Common Precursor for a Putative Hemorrhagic Protein and Rhodostomin, a Platelet Aggregation Inhibitor of the Venom of Calloselasma rhodostoma: Molecular Cloning and Sequence Analysis," Biochemical and Biophysical Research Communications, vol. 181, No. 2, pp. 585-593 (1991).
Blobel, et al., "A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion," Nature, vol. 356, pp. 248-252 (1992).
Calvete et al., "Identification of the Disulfide Bond Pattern in Albolabrin, and RGD-Containing Peptide from the Venom of Trimeresurus albolabris: Significance for the Expression of Platelet Aggregation Inhibitory Activity," Biochemistry, vol. 30, pp. 5225-5229 (1991).
Calvete, et al., "The Disulfide Bridge Pattern of Snake Venom Disintegrins, Flavoridin and Echistatin," FEBS Letters, vol. 309, No. 3, pp. 316-320 (1992).
Chang, et al., "Rhodostomin, An RGD-Containing Peptide Expressed From A Synthetic Gene In Escherichia coli, Facilitates The Attachment Of Human Hepatoma Cells," Biochemical and Biophysical Research Communications, vol. 190, No. 1 pp. 242-249 (1993).
Chao, et al., "Agkistrodon piscivorus piscivorus Platelet Aggregation Inhibitor: A Potent Inhibitor of Platelet Activation", Proc. Nat'l Acad. Sci. USA, vol. 86, pp. 8050-8054 (1989).
Chen, et al., "Proton NMR Assignments and Secondary Structure of the Snake Venom Protein Echistatin," Biochemistry, vol. 30, pp. 11625-11636 (1991).
Cooke et al., "Nuclear Magnetic Resonance Studies of the Snake Toxin Eschistatin .sup.1 H Resonance Assignments and Secondary Structure," Eur. J. Biochem, vol. 202, pp. 323-328 (1991).
Dalvit et al., ".sup.1 H NMR Studies of Echistatin in Solution--Sequential Resonance Assignments and Secondary Structure," Eur. J. Biochem, vol. 202, pp. 315-321 (1991).
Dennis et al., "Platelet Glycoprotein IIb-IIIa Protein Antagonists from Snake Venoms: Evidence for a Family of Platelet-Aggregation Inhibitors," Proc. Nat'l Acad. Sci. USA, vol. 87, pp. 2471-2475 (1990).
Dennis et al., "Binding Interactions of Kistrin With Platelet Glycoprotein IIb-IIIa: Analysis by Site-Directed Mutagenesis," Proteins: Structure, Function and Genetics, vol. 15, pp. 312-321 (1993).
Fecondo, et al., "Synthtic Peptide Analogs of Intercellular Adhesion Molecule 1 (ICAM-1) Inhibit HIV-1 Replication in MT-2 Cells," Aids Research and Human Retroviruses, vol. 9, No. 8, pp. 733-740 (1993).
Gan, et al., "Echistatin, A Potent Platelet Aggregation Inhibitor From the Venom of the Viper, Echis Carinatus", The Journal of Biological Chemistry, vol. 263, No. 36, pp. 19827-19832 (1988).
Garsky et al., "Chemical Synthesis of Echistatin, a Potent Inhibitor of Platelet Aggregation from Echis carinatus: Synthesis and Biological Activity of Selected Analogs," Proc. Nat'l Acad. Sci. USA, vol. 86, pp. 4022-4026 (1989).
Glander, et al., "Beta 1-integrins of spermatozoa: a flow cytophotometric analysis," International Journal of Andrology, vol. 16, pp. 105-111 (1993).
Glaser, "Work on Cell-Adhesion-Based Interactions Beginning to Bear Fruit," Genetic Engineering News, vol. 15, No. 20, pp. 6-7 (1995).
Gould et al., "Disintegrins: A Family of Integrin Inhibitory Proteins from Viper Venoms .sub.(43129B) "P.S.E.B.M., vol. 195, pp. 168-171 (1990).
Hardan, I., et al., Inhibition of Metastatic Cell Colonization in Murine Lungs and Tumor-Induced Morbidity by Nonpeptidic Arg-Gly-Asp Mimetics, 55 Int. J. Cancer 1023 (1993).
Hite, et al., "Sequence of a cDNA Clone Encoding the Zinc Metalloproteinase Hemorrhagic Toxin e from Crotalus atrox: Evidence for Signal, Zymogen, and Disintegrin-like Structures," Biochemistry, vol. 31, pp. 6203-6211 (1992).
Hite, et al., "cDNA Sequences for Four Snake Venom Metalloproteinases: Structure, Classification, and Their Relationship to Mammalian Reproductive Proteins," Archives of Biochemistry and Biophysics, vol. 308, No. 1, pp. 182-191 (1994).
Huang et al., "Mechanism of Action of the Antiplatelet Peptide, Arietin, From Bitis Arietans Venom," Biochimica et Biophysica Acta, vol. 1074 pp. 144-150 (1991).
Huang et al., "Purification and Characterization of an Antiplatelet Peptide, Arietin, from Bitis Arietans Venom", Biochimica et Biophysica Acta, vol. 1074, pp. 136-143 (1991).
Huang et al., "Triflavin, an Antiplatelet Arg-Gly-Asp-Containing Peptide, Is a Specific Antagonist of Platelet Membrane Glycoprotein IIb-IIIa Complex," J. Biochem, vol. 109, pp. 328-334 (1991).
Huang et al., "Halysin, an Antiplatelet Arg-Gly-Asp-Containing Snake Venom Peptide, As Fibrinogen Receptor Antagonist," Biochemical Pharmacology, vol. 42, No. 6, pp. 1209-1219 (1991).
Huang et al., "A Potent Antiplatelet Peptide, Triflavin, From Trimeresurus Flavoviridis Snake Venom," Biochem J., vol. 277, pp. 351-357 (1991).
Huang, et al., "Trigramin, A Low Molecular Weight Peptide Inhibiting Fibrinogen Interaction With Platelet Receptors Expressed on Glycoprotein IIb-IIIa Complex," The Journal of Biological Chemistry, vol. 262, No. 33, pp. 16157-16163 (1987).
Huang, et al., "Trigramin: Primary Structure and Its Inhibition of von Willebrand Factor Binding to Glycoprotein IIb/IIIa Complex on Human Platelets," Biochemistry, vol. 28, pp. 661-666 (1989).
Humphries, M.J., et al., Investigation of the Biological Effects of Anti-Cell Adhesive Synthetic Peptides that Inhibit Experimental Metastasis of B16-F10 Murine Melanoma Cells, 81 J. Clin. Invest. 782 (1988).
Kini et al., "Effects of Snake Venom Proteins on Blood Platelets," Toxicon, vol. 28, No. 12, pp. 1387-1422 (1990).
Kini et al., "Structural Domains in Venom Proteins: Evidence That Metalloproteinases and Nonenzymatic Platelet Aggregation Inhibitors (Disintegrins) From Snake Venoms are Derived by Proteolysis From A Common Precursor," Toxicon, vol. 30, No. 3, pp. 265-293 (1992).
Knudsen, et al., "Trigramin, an RGD-Containing Peptide from Snake Venom, Inhibits Cell-Substratum Adhesion of Human Melanoma Cells," Experimental Cell Research, vol. 179, pp. 42-49 (1988).
Mazur et al., "Ornatins: Potent Glycoprotein IIb-IIIa Antagonists and Platelet Aggreation Inhibitors From the Leech Placobdella Ornata," Eur. J. Biochem, vol. 202, pp. 1073-1082 (1991).
Musial, et al., "Inhibition of Platelet Adhesion to Surfaces of Extracorporeal Circuits by Disintegrins, RGD-Containing Peptides From Viper Venoms," Circulation, vol. 82, pp. 261-273 (1990).
Neeper et al., "Sequence of a cDNA Encoding the Platelet Aggregation Inhibitor Trigramin," Nucleic Acids Research, vol. 18, No. 14, p. 4255 (1990).
Omori-Satoh, et al., "Purification and Characterization of Cytotoxic Factors in the Venom of the Okinawa Habu (Trimeresurus Flavoviridis)," Toxicon, vol. 24, Nos. 11-12, pp. 1045-1053 (1986).
Paine et al., "Purification, Cloning, and Molecular Characterization of a High Molecular Weight Hemorrhagic Metalloprotease, Jararhagin, from Bothrops Jararaca Venom," The Journal of Biological Chemistry, vol. 267,

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