Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1982-01-13
1984-04-03
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
560 16, 548486, 562433, 562457, A61K 3119, C07C14943
Patent
active
044407858
ABSTRACT:
Novel 2-aminobiphenylacetic acids, esters and metal salts of the formula are disclosed: ##STR1## wherein R represents hydrogen, lower alkyl, sodium or potassium; R.sup.1 represents fluoro, chloro, bromo, lower-alkyl or amino; R.sup.2 represents lower-alkyl, lower-alkoxy, fluoro, chloro, bromo, amino or trifluoromethyl; and m and n are 0-2 with the proviso that when R.sup.1 or R.sup.2 are tertiary butyl or a sterically hindering lower alkyl radical, m and/or n are 1. The compounds are prepared by hydrolysis of 4-(5-, 6- and 7-)phenylindolin-2-ones to give the 2-amino-3-(4-, 5- and 6-)biphenylacetic acids. The free acids are converted to the esters and metal salts. The compounds have anti-inflammatory activity and inhibit blood platelet aggregation.
REFERENCES:
patent: 3466372 (1969-09-01), Shen et al.
patent: 3784704 (1974-01-01), Cohen et al.
patent: 3894080 (1975-07-01), Diamond et al.
patent: 3966978 (1976-06-01), Ellenbogen et al.
patent: 4048332 (1977-09-01), Adams et al.
A. H. Robins Company, Inc.
Daus Donald G.
Gibson S. A.
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