Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1995-06-05
1997-12-30
Draper, Garnette D.
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
514 2, 514 8, 530351, A61K 3820
Patent
active
057026980
ABSTRACT:
Methods are disclosed for promoting production of colony stimulating factor and inhibiting growth of Meth A tumor cells comprising administering a pharmaceutically effective amount of modified IL-1.alpha. to a subject.
REFERENCES:
patent: 4512974 (1985-04-01), Moldawer et al.
patent: 4542017 (1985-09-01), Moldawer et al.
patent: 4959314 (1990-09-01), Mark et al.
patent: 5017692 (1991-05-01), Zurawski et al.
patent: 5047505 (1991-09-01), Huang
patent: 5211946 (1993-05-01), Wallach et al.
patent: 5376639 (1994-12-01), Yamada et al.
patent: 5510462 (1996-04-01), Cheron et al.
patent: 5543140 (1996-08-01), Nakai et al.
March et al, "Cloning, Sequence and Expression of Two Distinct Human Interleukin-1 Complementary DNAs", Nature, 315(6021):641-647 (1985).
Wells et al, "Cassette Mutagenesis: An Efficient Method for Generation of Multiple Mutations at Defined Sites", Gene, 34:615-323 (1985).
Sato et al, "Recombinant Interleukin 1 Alpha and Beta Stimulate . . . ", Biochem. Biophys. Res. Comm., 141(1):285-291 (Nov. 1986).
Onazaki et al, "Human Interleukin 1 is a Cytocidal Factor for Several Tumor Cell Lines", J. Immunol. 135(6):3962-3968 (Dec. 1985).
Nakamura et al, "Antitumor Effect of Recombinant Human Interleukin 1 Alpha Against Murine Syngenic Tumors", Jpn. J. Cancer Res., 77:767-773 (Aug. 1986).
Chu et al, "Role of Interleukin 1 in Antigen-Specific T Cell Proliferation", J. Immunol., 132(3):1311-1316 (Mar. 1984).
Gaffney et al "Inhibition of Cell Growth by Interleukin 1 (IL-1)" Proc. Am. Assoc. Can. Res. 26:269, Abstract #1058 (Mar. 1985).
Matsushima et al, pp. 253-262 in The Physiologic, Metabolic and Immunologic Actions of Interleukin-1, (Alan R. Liss, Inc., NY, 1985).
Herman et al, "The Role of Interleukin 1 (IL 1) in Tumor-NK Cell Interactions . . . " J. Immunol. 135(4):2882-2886 (Oct. 1985).
Lachman et al "Natural and Recombinant Human Interleukin 1-.beta. is Cytotoxic . . . ", J. Immunol. 136(8):3098-3102 (Apr. 1986).
Onozaki et al, "Role of Interleukin 1 in Promoting . . . Tumor Cytotoxicity" J. Immunol. 135(1):314-320 (Ju. 1985).
Zucali et al, "Interleukin 1 Stimulates Fibroblasts . . . " J. Clin. Invest. 77:1857-1863 (Jun. 1986).
Hirai Yoshikatsu
Hong Yeong-Man
Ishii Kiyoshi
Kaneta Mayumi
Kawai Kazuyoshi
Draper Garnette D.
Otsuka Pharmaceutical Co. Ltd.
LandOfFree
Methods of use of IL-1.alpha. does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of use of IL-1.alpha., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of use of IL-1.alpha. will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-199943