Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or...
Patent
1997-10-14
2000-01-11
Chan, Christina Y.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
435375, 530324, 530327, 514 12, 514 14, C12N 138, C12N 1300, C07K 708, C07K 14435
Patent
active
06013495&
ABSTRACT:
The present invention provides a method for inhibiting cell proliferation in a cell comprising contacting the cell with a nucleic acid sequence or a polypeptide having essentially the sequence of the .beta..sub.1C integrin. Also included in the invention are peptides consisting of amino acid residues which are the size of or fewer than the sequence of the cytoplasmic domain of the .beta..sub.1C integrin consisting essentially of the amino acid sequence of SEQ ID NO:1 and SEQ ID NO:2, and functional fragments thereof which are useful for inhibiting cellular proliferation. Peptides, polynucleotides, and antibodies immunoreactive with the peptides, and methods of use for inhibiting cell growth are also provided.
REFERENCES:
patent: 5498694 (1996-03-01), Ruoshahti
patent: 5536814 (1996-07-01), Ruoslahti
Pasqualini, R and Hemler, ME. J. Cell Biol. 125(2):447-460, Apr. 1994.
Teague, T.K., and McIntyre, B.W. Cell Adhes. Comm. 2:169-184, 1994.
Fenczik, C.A. Nature. 390:81-85, Nov. 6, 1997.
Languino et al. (1992) J. Biol. Chem. 267, 7116-7120.
LaFlamme et al. (1992) J. Cell. Biol. 117, 437-447.
Ruoshati et al. (1994) Cell, 77, 477-478.
Languino Lucia
Meredith, Jr. Jere E.
Schwartz Martin A.
Takada Yoshikazu
Chan Christina Y.
The Scripps Research Institute
Tung Mary Beth
LandOfFree
Methods of use for integrin B.sub.1C cell growth inhibitor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of use for integrin B.sub.1C cell growth inhibitor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of use for integrin B.sub.1C cell growth inhibitor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1461514