Methods of treatment with drug loaded polymeric materials

Details Methods of treatment with drug loaded polymeric materials Methods of treatment with drug loaded polymeric materials

2007-07-30

2009-06-23

Desai, Anand U (Department: 1656)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

C514S002600, C530S350000, C977S773000

Reexamination Certificate

active

07550154

ABSTRACT:
Polymeric microparticles have been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and can have targeting ligands directly bound to the microparticle surface. Preferred applications include use in tissue engineering matrices, wound dressings, hone repair or regeneration materials, and other applications where the microparticles are retained at the site of application or implantation. Another preferred application is in the use of microparticles to deliver anti-proliferative agents to the lining of blood vessels following angioplasty, transplantation or bypass surgery to prevent or decrease restenosis, and in cancer therapy. In still another application, the microparticles are used to treat or prevent macular degeneration when administered to the eye, where agents such as complement inhibitors are administered.

REFERENCES:
patent: 4191743 (1980-03-01), Klemm
patent: 5543158 (1996-08-01), Gref et al.
patent: 5962566 (1999-10-01), Grandfils et al.
patent: 5972366 (1999-10-01), Haynes
patent: 6551990 (2003-04-01), Giachelli
patent: 6676963 (2004-01-01), Lanza et al.
patent: 6793938 (2004-09-01), Sankaram
patent: 2003/0235619 (2003-12-01), Allen et al.
patent: 2006/0051426 (2006-03-01), Golomb et al.
Anderson and Shive, et al., “Biodegradation and biocompatibility of PLA and PLGA microspheres”,Adv Drug Deliv Rev, 28(1):5-24 (1997).
Bourges, et al., “Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles”,Invest Ophthalmol Vis Sci, 44:3562-3569 (2003).
Bourla, et al., “Age-related macular degeneration: a practical approach to a challenging disease”,J. Am. Geriatr. Soc., 54(7):1130-5 (2006).
Brigger, et al., “Nanoparticles in cancer therapy and diagnosis”,Adv Drug Deliv Rev, 54:631-651 (2002).
Brunner, et al., “pH and osmotic pressure inside biodegradable microspheres during erosion”,Pharm Res, 16(6):847-53 (1999).
Cao, et al., “Production and surface modification of polylactide-based polymeric scaffolds for soft-tissue engineering”,Methods Mol Biol, 238:87-112 (2004).
Caponetti, et al., “Microparticles of novel branched copolymers of lactic acid and amino acids: preparation and characterization”,J Pharm Sci, 88(1):136-41 (1999).
Cho, et al., “Receptor-mediated delivery of all trans-retinoic acid to hepatocyte using poly(L-lactic acid) nanoparticles coated with galactose-carrying polystyrene”,J Control Release, 77:7-15 (2001).
Croll, “Controllable surface modification of poly(lactic-co-glycolic acid) (PLGA) by hydrolysis or aminolysis I: physical, chemical, and theoretical aspects”,Biomacromolecules, 5(2):463-73 (2004).
De Kozak, “Intraocular injection of tamoxifen-loaded nanoparticles: a new treatment of experimental autoimmune uveoretinitis”,Eur J Immunol, 34: 3702-3712 (2004).
Edwards, et al., “Complement Factor H Polymorphism and Age-Related Macular Degeneration”,Science, 308(5720):421-4 (2005).
Elamanchili, et al., “Characterization of poly(D,L-lactic-co-glycolic acid) based nanoparticulate system for enhanced delivery of antigens of dendritic cells”,Vaccine, 22:2406-2412 (2004).
Eliaz and Szoka, “Liposome-encapsulated doxorubicin targeted to CD44: a strategy to kill CD44-overexpressing tumor cells”,Cancer Res, 61: 2592-2601 (2001).
Eniola, et al., “Artificial polymeric cells for targeted drug delivery”,J Control Release87(1-3):15-22 (2003).
Evora, et al., “Relating the phagocytosis of microparticles by alveolar macrophages to surface chemistry: the effect of 1,2-dipalmitoylphosphatidylcholine”,J Control Release51(2-3):143-52 (1998).
Fahmy, “Increased TCR avidity after T cell activation: a mechanism for sensing low-density antigen”,Immunity, 14:135-43 (2001).
Faraasen, et al., “Ligand-specific targeting of microspheres to phagocytes by surface modification with poly(L-lysine)-grafted poly(ethylene glycol) conjugate”,Pharm Res, 20(2):237-46 (2003).
Garcia-Garcia, et al., “Drug-eluting stents”,Arch. Cardiol. Mex., 76(3):297-319 (2006) (abstract).
Guzman, et al., “Local intraluminal infusion of biodegradable polymeric nanoparticles. A novel approach for prolonged drug delivery after balloon angioplasty”,Circulation, 94:1441-1448 (1996).
Haines, et al., “Complement factor H variant increases the risk of age-related macular degeneration”,Science, 308(5720):419-21 (2005).
Hallahan, et al., “Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels”,Cancer Cell, 3:63-74 (2003).
Hammer, et al., “Synthetic cells-self-assembling polymer membranes and bioadhesive colloids”,Annu. Rev. Mater. Res., 31:387-40 (2001).
Hattori and Maitani, “Enhanced in vitro DNA transfection efficiency by novel folate-linked nanoparticles in human prostate cancer and oral cancer”,J. Control. Release, 97(1):173-83 (2004).
Hood, et al., “Tumor regression by targeted gene delivery to the neovasculature”,Science, 296(5577):2404-2407 (2002).
Huang, “Monoclonal antibody covalently coupled with fatty acid. A reagent for in vitro liposome targeting”,J Biol Chem, 255(17):8015-8 (1980).
Jain, “The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices”,Biomaterials, 21(23):2475-90 (2000).
Jansen, et al., “Encapsulation of Guest Molecules into a Dendritic Box”,Science, 266(5188):1226-1229 (1994).
Jansen, et al., “The Dendritic Box: Shape-Selective Liberation of shell deprotection Encapsulated Guests”,Journal of the American Chemical Society, 117:4417-4418 (1995).
Johansen, et al., “Revisiting PLA/PLGA microspheres: an analysis of their potential in parenteral vaccination”,Eur J Pharm Biopharm, 50(1):129-46 (2000).
Keegan, et al., “Biodegradable Microspheres with Enhanced Capacity for Covalently Bound Surface Ligands”Macromolecules, 37:9979-84 (2004).
Keegan, et al., “Biomimetic design in microparticulate vaccines”,Biomaterials, 24(24):4435-4443 (2003).
Klein, et al., “Complement factor H polymorphism in age-related macular degeneration”,Science, 308(5720):385-9 (2005).
Kobayashi, “Evaluation of the in vivo biodistribution of indium-111 and γttrium-88 labeled dendrimer-1B4M-DTPA and its conjugation with anti-Tac monoclonal antibody”,Bioconjug Chem, 10:103-11 (1999).
Kobayashi, et al., “Dendrimer-based Macromolecular MRI Contrast Agents: Characteristics and Application”,Mol Imaging, 2:1-10 (2003).
Kompella, et al., “Subconjunctival nano- and microparticles sustain retinal delivery of budesonide, a corticosteroid capable of inhibiting VEGF expression”,Invest. Ophthalmol. Vis. Sci., 44(3):1192-201 (2003).
Kono, et al.,Abstracts of Papers of the American Chemical Society, 221:U377-U377 (2001).
Labhasetwar, et al., “Arterial uptake of biodegradable nanoparticles: effect of surface modifications”,J Pharm Sci, 87:1229-1234 (1998).
Lamprecht, et al., “Biodegradable nanoparticles for targeted drug delivery in treatment of inflammatory bowel disease”,J Pharmacol Exp Ther, 299(2):775-81 (2001).
Langer and Folkman, “Polymers for the sustained release of proteins and other macromolecules”,Nature, 263(5580):797-800 (1976).
Lathia, et al., “Polymeric contrast agent with targeting potential”,Ultrasonic, 42(1-9):763-8 (2004).
Lavik, et al., “A simple synthetic route to the formation of a block copolymer of poly(lactic-co-glycolic acid) and polylysine for the fabrication of functionalized, degradable structures for biomedical applications”,J Biomed Mater Res, 58(3):291-4 (2001).
Liu, et al.,Abstracts of Papers of the American Chemical Society, 216:U875-U875 (1998).
Lopes De Menezes, et al., “In v

Affiliated with

Also associated with

Rating

Methods of treatment with drug loaded polymeric materials does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of treatment with drug loaded polymeric materials, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of treatment with drug loaded polymeric materials will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4139739