Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1992-07-22
1993-06-15
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424457, 424458, 424459, 424468, 424490, 424497, 514821, A61K 916, A61K 958
Patent
active
052196216
ABSTRACT:
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane surrounding the core and containing a major proportion of a pharmaceutically acceptable film-forming, water insoluble synthetic polymer and a minor proportion of a pharmaceutically acceptable film-forming, water soluble synthetic polymer. The number of layers in the membrane and the ratio of the water soluble to water insoluble polymer being effective to permit release of diltiazem from the pellet at a rate allowing controlled absorption thereof over a twelve hour period following oral administration. The pellet has a dissolution rate in vitro which when measured in a dissolution apparatus (Paddle) according to U.S. Pharmacopoeia XXI in 0.05 M KCl at pH 7.0 results in not more than 35% of the total diltiazem being released after 2 hours of measurement. Not more than 80% of the total diltiazem is released after six hours of measurement and not less than 85% of the total diltiazem is released after 13 hours of measurement.
REFERENCES:
patent: 2853420 (1958-09-01), Lowey
patent: 4443497 (1984-04-01), Samejima
patent: 4459279 (1984-07-01), Stricker
patent: 4496558 (1985-01-01), DeMarinis
patent: 4681755 (1987-07-01), Colombo et al.
patent: 4721619 (1988-01-01), Panoz et al.
patent: 4747845 (1988-05-01), Korol
patent: 4786500 (1988-11-01), Wong
patent: 4792452 (1988-12-01), Howard
Pharmacotherapy, 1982; 2:121-123-"The Use of Diltiazem Hydrochloride in Cardiovascular Disorders," Bruce J. McAuley, M.D., and John S. Schroeder, M.D.
Modern Pharmaceutics (1979) (vol. 6, pp. 138-161)-"Sustained and Controlled Release Drug Delivery Systems," edited by Joseph R. Robinson.
Am. J. of Cardiology 49:530-532-"The Pharmacokinetics of Diltiazem in Healthy American Men," Robert F. Zelis, M.D., FACC, Evlin L. Kinney, M.D.
Geoghegan Edward J.
Mulligan Seamus
Panoz Donald E.
Church Marla J.
Elan Corporation, plc
Page Thurman K.
Spear James M.
LandOfFree
Methods of treatment with diltiazem formulations does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of treatment with diltiazem formulations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of treatment with diltiazem formulations will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1041155