Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-12-29
1999-10-12
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3135
Patent
active
059656069
ABSTRACT:
Retinoid compounds which act specifically or selectively on RAR.sub..alpha. receptor subtypes in preference over RAR.sub..beta. and RAR.sub..gamma. receptor subtypes, posses desirable pharmaceutical properties associated with retinoids, and are particularly suitable for treatment of tumors, such as acute monocytic leukemia, cervical carcinoma, myeloma, ovarian carcinomas and head and neck carcinomas, without having one or more undesirable side effects of retinoids, such as inducement of weight loss, mucocutaneous toxicity, skin irritation and teratogenecity.
REFERENCES:
patent: 5420145 (1995-05-01), Shudo
Kagechike et al., J. Med Chem, 1988, 31, 2182-2192.
Chemical Abstracts, vol. 121, No. 9, 1994.
Chandraratna Roshantha A.
Duong Tien T.
Teng Min
Allergan Sales Inc.
Baron Robert J.
Goldberg Jerome D.
Szekeres Gabor L.
Voet Martin A.
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