Methods of treatment using IL-16 antagonist peptides

Details Methods of treatment using IL-16 antagonist peptides Methods of treatment using IL-16 antagonist peptides

2011-03-29

2011-03-29

Bunner, Bridget E (Department: 1647)

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

C530S328000, C530S329000, C514S016700, C514S017400

Reexamination Certificate

active

07914778

ABSTRACT:
The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The present invention has demonstrated that such IL-16-inhibiting peptides can be as short as 4 amino acids in length. Based on these discoveries, the present invention provides IL-16 antagonist peptides and the use thereof for the treatment of IL-16 mediated disorders such as certain inflammatory diseases.

REFERENCES:
patent: 5350836 (1994-09-01), Kopchick et al.
patent: 6159463 (2000-12-01), Center et al.
patent: 6699466 (2004-03-01), Center et al.
patent: 19649233 (1998-04-01), None
patent: WO 94/28134 (1994-12-01), None
patent: WO 99/37781 (1999-07-01), None
patent: WO 99/48514 (1999-09-01), None
Glass et al. Not-so-sweet sixteen: the role of IL-16 in infectious and immune-mediated inflammatory disorders. J Interferon Cytokine Res 26: 511-520, 2006.
Skolnick et al. (2000) “From genes to protein structure and function: novel applications of computational approaches in the genomic era”,Trends in Biotech18(1): 34-39.
Bork, A. (2000) “Powers and pitfalls in sequence analysis: the 70% hurdle”,Genome Res10: 398-400.
Doerks et al. (1998) “Protein annotation: detective work for function prediction”,Trends in Genetics14 (6): 248-250.
Smith et al. (1997) The challenges of genome sequence annotation or “The devil is in the details”,Nature Biotech15: 1222-1223.
Brenner, S. E. (1999) “Errors in genome function”,Trends in Genetics(15)4): 132-133.
Bork et al. (1996) “Go hunting in sequence databases but watch out for traps”Trends in Genetics12(10): 425-427.
Wells, J. A. (1990) “Additivity of mutational effects in proteins”,Biochemistry29(37): 8509-8517.
Ngo et al. (1994) “Computational complexity, protein structure prediction, and the Levinthal paradox”,The Protein Folding Problem and Tertiary Structure Prediction492-495.
Center et al. (1982) “Modulation of lymphocyte migration of human lymphokines; identification and characterization of chemoattractant activity for lymhocytes from mitogen-stimulated mononuclear cells”,J Immunol128 (6) 2563-2568.
Cruikshank et al. (1994) “Molecular and functional analysis of a lymphocyte chemoattractant factor: Association of biologic function with CD4 expression”,Proc Natl Acad Sci USA91: 5109-5113.
Cruikshank et al. (1991) “Lymphocyte chmoattractant factor induces CD4-dependent intracytoplasmic signaling in lymphocytes”,J Immunol146: 2928-2934.
Cruikshank et al. (1996) “Biological activity of interleukin-16”,Nature382 (6591): 501-502.
Nicoll et al. (1999) “Identification of domains in IL-16 critical for biological activity”,J Immunol163: 1827-1832.
Liu et al. (1999) “Identification of a CD4 domain required for interleukin-16 binding and lymphocyte activation”,J Biol Chem274(33): 23387-23395.
de Bie et al. (1999) “Effects of interleukin-16-blocking peptide on parameters of allergic asthma in a murine model”,Eur J Pharmacol383: 189-196.
IUIS/WJO Standing Committee on Interleukin Designation (1995) “Interleukin 16”,Eur J Immunol26: 1196.
Bannert et al. (1998) “Molecular cloning and sequence analysis of interluekin 16 from nonhuman primates and from the mouse”,Immunogenetics47: 390-397.
Keane et al. (1998) “Conservation of structure and function between human and murine Il-16”,J Immunol160: 5945-5954.

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