Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Reexamination Certificate
2011-01-04
2011-01-04
Lukton, David (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
C530S300000, C530S325000, C530S326000, C530S327000, C530S328000, C530S329000, C530S330000, C514S002600
Reexamination Certificate
active
07863414
ABSTRACT:
The present invention provides for methods of treating and cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension comprising the use of CaMKII-HDAC binding domains. The present invention discloses not only the fact that CaMKII binds to HDAC4 at a specific site, but that HDAC4 may dimerize with other HDACs. Both events can lead to export of HDACs from the nucleus to the cytoplasm, an event associated with the development of heart disease. Thus the methods of treatment and the screening methods of the present invention are novel attempts to prevent, treat or identify therapies for cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension.
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Backs Johannes
Harrison Brooke
Huynh Khai
Koch Keith
McKinsey Timothy A.
Fulbright & Jaworski
Gilead Sciences, Inc.
Lukton David
The Board of Regents of the University of Texas Systems
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