Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1992-09-17
1993-12-07
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 88, A61K 3904, A61K 3902
Patent
active
052681700
ABSTRACT:
A Mycobacterium bovis BCG polypeptide having a molecular mass of about 64 kD was found to be useful as an immunogen inducing resistance to autoimmune arthritis and similar autoimmune diseases.
The invention relates to methods of treatment and diagnosis of autoimmune diseases especially arthritic conditions, in which said polypeptide is used.
The invention also relates to a polypeptide comprising the epitope essential for this activity. The polypeptide has the formula ##STR1## Further, the invention relates to polypeptides showing sequential homology with said polypeptide, and to derivatives and multimers thereof. Also, microorganisms expressing the polypeptides either as such or as part of a fusion protein or as a multimer, form part of the invention.
Finally, the invention relates to pharmaceutical compositions, diagnostic compositions and test kits comprising a compound according to the invention.
REFERENCES:
Infection and Immunity, vol. 50. 50, No. 3, Dec. 1985, pp. 800-806, American Society for Microbiology, WA., US.
J. E. R. Thole et al.: "Cloning of Mycobacterium bovis BCG DNA and expression of antigens in Escherichia coli".
Young et al.: "Dissection of Mycobacterium tuberculosis antigens using recombinant DNA".
Chemical Abstracts, vol. 105, No. 17, Oct. 27, 1986, p. 525, Abstract No. 151096y, Columbus, OH, US; W. J. Britton et al.
"Immunoreactivity of a 70 kD protein purified from Mycobacterium bovis Bacillus Calmette-Guerin by monoclonal antibody affinity chromatography", and J. Exp. Med. 1986, 164(3), 695-708. Abs.
Proc. Natl. Acad. Sci. vol. 82, May 1985, pp. 2583-2587; R. A.
The Etiologic Agents of Leprosy and Tuberculosis Share an Immunoreactive Protein Antigen with the Vaccine Strain Mycobacterium bovis BCG, Inf. Immunity, 55:1932-1935, Shinnick, et al.
A Recombinant 64 Kilodalton Protein of Mycobacterium bovis Bacillus Calmette-Guerin Specifically Stimulates Human T4 Clones Reactive to Mycobacterial Antigens, J. Exp. Med. 163:1024-1029 (1986), Emmrich et al.
Evidence for an HLA-DR4-Associated Immune-Response Gene For Mycobacterium Tuberculosis, The Lancet, 2:310-313, 1986, Ottenhoff.
Characterization, Sequence Determination and Immunogenicity of a 64-Kilodalton Protein of Mycobacterium bovis BCG Expressed in Escherichia Coli K-12, Inf. Immunity, 55:1466-1475 (1987) Thole et al.
Cohen Irun R.
Thole Jelle E. R.
Van der Zee Ruurd
van Eden Willem
Van Embden Johannes D. A.
Nucker Christine M.
Sidberry H.
Yeda Research and Development Co. Ltd.
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