Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1994-11-30
1996-08-20
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
A61K 3159
Patent
active
055479472
ABSTRACT:
A method of inducing inhibition or loss of cell proliferation in solid tumors utilizing a Vitamin D.sub.3 analog, as well as a method of inducing loss of cell proliferation in solid tumors utilizing trans retinoic acid and a Vitamin D.sub.3 analog.
In another aspect, a method of inducing inhibition or loss of cell proliferation in solid tumors utilizing a Vitamin D.sub.3 metabolite, as well as a method of inducing loss of cell proliferation in solid tumors utilizing trans retinoic acid and a Vitamin D.sub.3 metabolite.
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Zhou, et al., Development of a Novel 1,25-(OH).sub.2 -Vitamin D.sub.3 Analog With Potent Ability to Induce HL-60 Cell Differentiation Without Modulating Calcium Metabolism: Blood, vol. 78, No. 1, pp. 75-82, Jul. 1, 1991.
Proceeding of Am Association for Cancer Research, vol. 34, Mar. 1993.
Dore Benoit T.
Momparler Richard L.
Uskokovic Milan R.
Ciambrone Coletti Ellen
Goldberg Jerome D.
Hoffmann-La Roche Inc.
Johnston George W.
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