Methods of treating type I hypersensitivity using monophosphoryl

Details Methods of treating type I hypersensitivity using monophosphoryl Methods of treating type I hypersensitivity using monophosphoryl

1996-05-14

1998-06-09

Hutzell, Paula K.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Allergen or component thereof

4242751, 4242831, 4242821, 4242341, 4242571, 4241971, 424422, 424418, 424182, 424177, 424195, 424400, 424450, 424 7013, 514 54, 514960, 514 2, 530329, 536 5, 536124, A61K 3935, A61K 4500, A61K 3902

Patent

active

057629439

ABSTRACT:
Methods and compositions for treating type I immunoglobin E (IgE)-dependent hypersensitivity by the administration of monophosphoryl lipid A (MLA) or 3-deacylated monophosphoryl lipid A (3D-MLA) are disclosed. MLA or 3D-MLA administered alone or in combination with an allergen to a patient suffering from type I hypersensitivity reduces levels of total or allergen specific IgE and increases levels of IgG antibody in that patient. MLA and 3D-MLA can be administered as part of a desensitization regimen or as a component of a prophylactic vaccine to prevent a type I hypersensitivity reaction.

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patent: 5073628 (1991-12-01), Matsuhashi et al.
patent: 5244663 (1993-09-01), Bruttmann et al.

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