Methods of treating tumors susceptible to necrosis

Details Methods of treating tumors susceptible to necrosis Methods of treating tumors susceptible to necrosis

1987-03-26

1989-06-06

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3140

Patent

active

048372218

ABSTRACT:
This invention provides for therapy of tumours susceptible to necrosis by a porphyrin when an appropriate porphyrin compound is administered to locate in the tumor followed by illumination with light of a wavelength absorbed by the compound, making use of meso-porphyrins of the formula: ##STR1## where n=1 to 3 and each substitutent R, the same or different and at the same or different position in its respective substituent phenyl ring or other aromatic group replacing that ring, is an hydroxy, amino or sulphydryl group, by association of said meso-porphyrins with a suitable pharmaceutical diluent or carrier.

REFERENCES:
patent: 3988436 (1976-10-01), Loo
patent: 4393071 (1983-07-01), Fujii et al.
patent: 4656186 (1987-04-01), Bommer et al.
Chemical Abstracts 100: 85666c (1984).
Chemical Abstracts 103: 50054m (1985).

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