Methods of treating rheumatoid arthritis with anti-TNF...

Details Methods of treating rheumatoid arthritis with anti-TNF... Methods of treating rheumatoid arthritis with anti-TNF...

2007-06-18

2008-08-26

Gambel, Phillip (Department: 1644)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C424S130100, C424S133100, C424S141100, C424S158100, C530S387100, C530S387300, C530S388100, C530S388200, C530S388230

Reexamination Certificate

active

07416729

ABSTRACT:
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

REFERENCES:
patent: 4603106 (1986-07-01), Cerami et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4822776 (1989-04-01), Cerami et al.
patent: 5075236 (1991-12-01), Yone et al.
patent: 5223395 (1993-06-01), Gero
patent: 5231024 (1993-07-01), Moeller et al.
patent: 5342613 (1994-08-01), Creaven et al.
patent: 5360716 (1994-11-01), Ohmoto et al.
patent: 5436154 (1995-07-01), Barbanti et al.
patent: 5654407 (1997-08-01), Boyle et al.
patent: 5656272 (1997-08-01), Le et al.
patent: 5658570 (1997-08-01), Newman et al.
patent: 5698195 (1997-12-01), Le et al.
patent: 5700788 (1997-12-01), Mongelli et al.
patent: 5730975 (1998-03-01), Hotamisligil et al.
patent: 5741488 (1998-04-01), Feldman et al.
patent: 5750105 (1998-05-01), Newman et al.
patent: 5776947 (1998-07-01), Kroemer et al.
patent: 5888511 (1999-03-01), Skurkovich et al.
patent: 5919452 (1999-07-01), Le et al.
patent: 5958413 (1999-09-01), Anagnostopulos et al.
patent: 5959087 (1999-09-01), Rathjen et al.
patent: 5993833 (1999-11-01), De Lacharriere et al.
patent: 6015558 (2000-01-01), Hotamisligil et al.
patent: 6172202 (2001-01-01), Marcucci et al.
patent: 6190691 (2001-02-01), Mak
patent: 6194451 (2001-02-01), Alpegiani et al.
patent: 6277969 (2001-08-01), Le et al.
patent: 6284471 (2001-09-01), Le et al.
patent: 6309640 (2001-10-01), Cerami et al.
patent: 6419927 (2002-07-01), Cerami et al.
patent: 6790444 (2004-09-01), Le et al.
patent: 6835823 (2004-12-01), Le et al.
patent: 6991791 (2006-01-01), Le et al.
patent: 7070775 (2006-07-01), Le et al.
patent: 7101674 (2006-09-01), Le et al.
patent: 7128907 (2006-10-01), Le et al.
patent: 7128908 (2006-10-01), Le et al.
patent: 7135178 (2006-11-01), Le et al.
patent: 7135179 (2006-11-01), Le et al.
patent: 7138118 (2006-11-01), Le et al.
patent: 7160542 (2007-01-01), Le et al.
patent: 7160543 (2007-01-01), Le et al.
patent: 7160995 (2007-01-01), Le et al.
patent: 7166284 (2007-01-01), Le et al.
patent: 7169386 (2007-01-01), Le et al.
patent: 7169388 (2007-01-01), Le et al.
patent: 7179466 (2007-02-01), Le et al.
patent: 7179893 (2007-02-01), Le et al.
patent: 7192584 (2007-03-01), Le et al.
patent: 7204985 (2007-04-01), Le et al.
patent: 7214376 (2007-05-01), Le et al.
patent: 7223396 (2007-05-01), Le et al.
patent: 7226593 (2007-06-01), Le et al.
patent: 7227003 (2007-06-01), Le et al.
patent: 7252823 (2007-08-01), Le et al.
patent: 7276239 (2007-10-01), Le et al.
patent: 2002/0146419 (2002-10-01), Le et al.
patent: 2003/0147891 (2003-08-01), Le et al.
patent: 2004/0115200 (2004-06-01), Le et al.
patent: 2004/0138427 (2004-07-01), Le et al.
patent: 2005/0249735 (2005-11-01), Le et al.
patent: 2005/0255104 (2005-11-01), Le et al.
patent: 2005/0260201 (2005-11-01), Le et al.
patent: 2006/0024310 (2006-02-01), Le et al.
patent: 2006/0140946 (2006-06-01), Le et al.
patent: 2006/0140949 (2006-06-01), Le et al.
patent: 2007/0087003 (2007-04-01), Le et al.
patent: 2007/0141057 (2007-06-01), Le et al.
patent: 2007/0196373 (2007-08-01), Le et al.
patent: 0 212 489 (1987-03-01), None
patent: 0 218 868 (1987-04-01), None
patent: 0 260 610 (1988-03-01), None
patent: 0 288 088 (1988-10-01), None
patent: 0 350 690 (1990-01-01), None
patent: 0 351 789 (1990-01-01), None
patent: 0 351 789 (1990-01-01), None
patent: 0 380 068 (1990-08-01), None
patent: 0387095 (1990-09-01), None
patent: 0 393 438 (1990-10-01), None
patent: 0 453 898 (1991-10-01), None
patent: 0 486 526 (1992-05-01), None
patent: 0 512 528 (1992-11-01), None
patent: 0 526 905 (1993-02-01), None
patent: 0 585 705 (1994-03-01), None
patent: 0 614 984 (1994-09-01), None
patent: 0 308 378 (1994-11-01), None
patent: 0 412 486 (1994-11-01), None
patent: 0 101 681 (1994-12-01), None
patent: 0 398 327 (1995-03-01), None
patent: 0 433 900 (1995-09-01), None
patent: 0 663 836 (1997-07-01), None
patent: 61-047500 (1986-03-01), None
patent: 1961/047500 (1986-03-01), None
patent: 02-227095 (1990-09-01), None
patent: 2002/227095 (1990-09-01), None
patent: WO 89/08460 (1989-09-01), None
patent: WO 90/00902 (1990-02-01), None
patent: WO 90/01950 (1990-03-01), None
patent: WO 91/02078 (1991-02-01), None
patent: WO 91/04054 (1991-04-01), None
patent: WO 91/09967 (1991-07-01), None
patent: WO 92/01059 (1992-01-01), None
patent: WO 92/01472 (1992-02-01), None
patent: WO 92/07076 (1992-04-01), None
patent: WO 92/11383 (1992-07-01), None
patent: WO 92/13095 (1992-08-01), None
patent: WO 92/16553 (1992-10-01), None
patent: WO 93/02108 (1993-02-01), None
patent: WO 93/11236 (1993-06-01), None
patent: WO 94/08609 (1994-04-01), None
patent: WO 94/08619 (1994-04-01), None
U.S. Appl. No. 11/792,734, by Junming Le, Jan T. Vilcek, Peter E. Daddona, John Ghrayeb, David M. Knight, Scott A. Siegel, and David J. Shealy, filed Dec. 13, 2005.
U.S. Appl. No. 11/401,391, by Junming Le, Jan T. Vilcek, Peter Daddona, John Ghrayeb, David M. Knight and Scott A. Siegel, filed Apr. 10, 2006.
U.S. Appl. No. 11/713,534, by Junming Le, Jan T. Vilcek, Peter E. Daddona, John Ghrayeb, David M. Knight, Scott A. Siegel and David J. Shealy, filed Mar. 2, 2007.
U.S. Appl. No. 11/891,036, by Junming Le, Jan T. Vilcek, Peter E. Daddona, John Ghrayeb, David M. Knight and Scott A. Siegel, filed Aug. 8, 2007.
Aderka, D., et al., “IL-6 Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor Production in Cultured Human Monocytes, U937 Cells, and in Mice,”The Journal of Immunology, 143: 3517-3523 (1989).
Aderka, D., et al., “The Possible Role of Tumor Necrosis Factor (TNF) and Its Natural Inhibitors, The Soluble-TNF Receptors, In Autoimmune Diseases,”Israel J Med Sci., 28(2): 126-130 (1992).
Aderka, D., “Role of Tumor Necrosis Factor in the Pathogenesis of Intravascular Coagulopathy of Sepsis: Potential New Therapeutic Implications,”Israel Journal of Medical Sciences, 27: 52-60 (1991).
Aggarwal, B., et al , “Human Tumor Necrosis Factor Production, Purification and Characterization,”J. of Biol. Chem., 260(4): 2345-2354 (1985).
Akama, H., et al., “Mononuclear Cells Enhance Prostaglandin E2Production of Polymorphonuclear Leukocytes via Tumor Necrosis Factor α,”Biochemical and Biophysical Research Comm., 168(2): 857-862 (1990).
Alberts, B., et al., Molecular Biology of the Cell, Garland Publishing Inc., pp. 182-183 (1983).
Barbanti, E., et al , “A High-affinity Neutralizing Anti-human TNF-alpha Monoclonal Antibody That Cross-reacts With Human TNF-beta,” Abstracts, Mar. 6-9, 1991.
Barbuto, J.., “Production of Neutralizing Antibodies to Tumor Necrosis Factor by Human Tumor-infiltrating B Lymphocytes,”Proceedings of the American Association for Cancer Research, 34: 487, Abstract 2904, (1993).
Bendtzen, K., et al., “Auto-Antibodies To IL-1α and TNFα In Normal Individuals And In Infectious And Immunoinflammatory Disorders,”The Physiological and Pathological Effects of Cytokines, 10B: 447-452 (1990).
Bendtzen, K., et al., “Native Inhibitors (Autoantibodies) of IL-1α and TNF,”Immunology Today, 10(7): 222 (1989).
Beutler, B., et al., “Identity of Tumour Necrosis Factor and the Macrophage-secreted Factor Cachectin,”Nature, 316: 552-554 (1985).
Beutler, B., et al., “Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin,”Science, 229: 869-871 (1985).
Beutler, B., et al., “Purification of Cachectin, A Lipoprotein Lipase-Suppressing Hormone Secreted by Endotoxin-induced RAW 264.7 Cells,”J. Exp. Med, 161: 984-995 (1985).
Beutler, B., et al., “Cachectin and Tumour Necr

Affiliated with

Also associated with

Rating

Methods of treating rheumatoid arthritis with anti-TNF... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of treating rheumatoid arthritis with anti-TNF..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of treating rheumatoid arthritis with anti-TNF... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3996471