Methods of treating or preventing breast or endometrial cancer w

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

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514170, 514177, 514179, A01N 4500, A61K 3156

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active

053627202

ABSTRACT:
A method of treatment or prevention of breast and endometrial cancer, osteoporosis and endometriosis in susceptible warm-blooded animals comprising administering a low dose of a progestin or other steroid derivative having androgenic activity and low masculinizing activity. Pharmaceutical compositions useful for such treatment and pharmaceutical kits containing such compositions are disclosed. An in vitro assay permitting specific measurements of androgenic activity of potentially useful compounds is also disclosed.

REFERENCES:
patent: 2875199 (1959-02-01), Cella et al.
patent: 3493606 (1970-02-01), Richardson
patent: 3562260 (1971-02-01), Ruggieri et al.
patent: 3637856 (1972-01-01), Richardson
patent: 3995060 (1976-11-01), Neri et al.
patent: 4071622 (1978-01-01), Johnson
patent: 4094994 (1978-06-01), Schonenberger
patent: 4096253 (1978-06-01), Watchter et al.
patent: 4139638 (1979-02-01), Neri et al.
patent: 4161540 (1979-07-01), Neri et al.
patent: 4198435 (1980-04-01), Richardson
patent: 4307111 (1981-12-01), Crawley
patent: 4386080 (1983-05-01), Crossley et al.
patent: 4472382 (1984-09-01), Labrie
patent: 4522831 (1985-06-01), Chatterton, Jr.
patent: 4536516 (1985-08-01), Harper et al.
patent: 4623660 (1986-11-01), Richardson
patent: 4636505 (1987-01-01), Tucker et al.
patent: 4659516 (1987-04-01), Bowler et al.
patent: 4659695 (1987-04-01), Labrie
patent: 4728640 (1988-03-01), Labrie et al.
patent: 4732912 (1988-03-01), Pilgrim et al.
patent: 4743589 (1988-05-01), Labrie et al.
patent: 4745102 (1988-05-01), Labrie et al.
patent: 4751240 (1988-06-01), Bowler et al.
patent: 4760053 (1988-07-01), Labrie
patent: 4760061 (1988-07-01), Edwards et al.
patent: 4775660 (1988-10-01), Labrie
patent: 4775661 (1988-10-01), Labrie
patent: 4826831 (1989-05-01), Plunkett et al.
patent: 4833135 (1989-05-01), Edwards et al.
patent: 5043331 (1991-08-01), Hirvomen et al.
B. Tobias, et al., J. Biol. Chem., 257, 2783-2786, 1982.
R. J. Auchus, et al., Biochemistry, 25, 7295-7300, 1986.
Levesque, et al. J. Med. Chem., 34, (1991), pp. 1624-1630.
Heiman, et al., J. Med. Chem., 23, (1980), pp. 994-1002.
Fevig, et al., Steroids, 51 (1988), pp. 471-497.
R. T. Blickenstaff, et al., "Synthesis of Some Analogs of Estradiol", Steroids, vol. 46, No. 4, 5, Nov. (1985), pp. 889-902.
Wakeling, et al., "Steroidal Pure Antioestrogens", J. Endocrinol. (1987), 112, R7-R10.
H. Mouridsen, et al., Cancer Treatment Review 5, 131-141, (1978).
Klijn, et al., J., J. Steroid BioChem. 420, No. 66, 1381 (1984).
Wakeling, et al., J. Steroid BioChem., 30:141-147, 1988.
Bucourt, et al. J. Biol. Chem., 253:8221, 1978.
Thomas, et al. J. Biol. Chem., 258:11500, 1983.
Albright et al., In: The Parathyroid Glands & Metabolic Bone Disease, Williams & Williams Co: Baltimore, pp. 145-204, 1988.
Aloia et al., Metabolism, vol. 30, No. 11, pp. 1067-1079 (1981).
Asselin et al., Cancer Res., vol. 40, pp. 1612-1622 (1980).
Baran et al., Calif. Tissue Res. 26:103-106, 1978.
Bryan et al., Cancer 54: 2436-2440, 1984.
Bullock et al., Endocrinology 103: 1768-1782, 1978.
Chessnut et al. Metabolism 26: 267-277, 1977.
Chessnut et al., Metabolism 32:571-580, 1983.
Clavel et al., Eur J. Cancer Clin. Oncol. 18:821-826, 1982.
Cooperative Breast Cancer Group, JAMA 188, 1069-1072, 1964.
Cremonicini et al., Acta. Eur. Fertil. 7:248-314, 1976.
Cusan et al., J. Am. Acad. Dermatol. 23:462-469, 1990.
Dauvois & Labrie (Unpublished data).
Dequeker & Geusens, Acta Endocrimol 271 (Suppl):45-52, 1985.
Dhem, A., Ars-Piret N., Waterschoot MP (9180) Curr. Med. Res. Opin. 6: 606-613.
Dickson & Lippman, Endocr. Rev. 8:29-43, 1987181, 1975.
Dixon et al., Clinical Endocrinology 30: 271-277, 1989.
Earl et al., Clin. Oncol. 10:103-109, 1984.
Engel et al., Cancer Res. 38: 3352-3364, 1978.
Engelsman et al., British J. Cancer 30: 177-181, 1975.
Ferriman & Gallwey, J. P. Clin Endocrimol. Metab 21: 1440-1447, 1961.
Telimaa et al., Gynecol. Endocrinol. 1:13, 1987.
Tormey et al., Ann. Int. Med. 98: 139-144, 1983.
Furr, et al., J. Endocr. 113, R7-R9, 1987.
Jordan, et al. "Regulation of Prolactin Synthesis in Vitro By Estrogenic and Antiestrogenic Derivatives of Estradiol and Estrone", Endocrinology, 124(4): 1717-1725 (1989).
C. C. Chin, et al., J. Biol. Chem., 250, 7682-7686, 1975.
Y. M. Bhatnagar, et al. J. Biol. Chem. 253, 811-815, 1978.
C. C. Chin, et al., J. Biol. Chem., 255, 3660-3664, 1980.
J. L. Thomas, et al., J. Biol. Chem., 258, 1587-1590, 1983.
Von Angerer, et al., J. Med. Chem., 27:1439-1447, 1984.
Landvatter, et al., "Non-Steroidal Estrogens: Synthesis and Estrogen Receptor Binding Affinity of Derivatives of . . . ", J. Med. Chem. 1982.
Weatherill, et al., "Interactino of Antiestrogen ICI 164, 384 with Oestrogen Receptor", J. Steroid Biochem., vol. 30, No. 1-6, pp. 263-266 (1988).
Doberauer, et al., "Advanced Male Breast Cancer Treatment with the LH-RH Analog Buser . . . Cancer", 62: pp. 474-478, (1988).
Sinard, et al. Mec. Endocrinol 2:775-784 (1988).
U.S. Application: 07/699,710, Filed Feb. 8, 1984.
U.S. Application: 07/146,597, Filed Jan. 21, 1988.
U.S. Application: 07/265,150, Filed Oct. 31, 1988.
U.S. Application: 07/265,716, Filed Nov. 1, 1988.
U.S. Application: 07/321,926, Filed Mar. 10, 1989.
U.S. Application: 07/322,154, Filed Mar. 10, 1989.
U.S. Application: 07/376,696, Filed Jul. 7, 1989.
U.S. Application: 07/376,700, Filed Jul. 7, 1989.
U.S. Application: 07/376,710, Filed Jul. 7, 1989.
U.S. Application: 07/413,613, Filed Nov. 9, 1989.
Adair, Surg. Gynecol. Obstet. 84: 719-722, 1947.
Adair et al., JAMA 140: 1193-2000, 1949.
Adair and Herrmann, Ann. Surg. 123: 1023-1035, 1946.
Allegra et al., Cancer Res. 39: 1447-1454, 1979.
Aloia et al., Arch. Int. Med. 143: 1700-1704, 1983.
Blossey et al., Cancer 54: 1208-1215, 1984.
Blumenschein, Semin. Oncol. 10: 7-10, 1983.
Centola, Cancer Res. 45: 6264-6267, 1985.
Chemical Abstracts, vol. 97, No. 4, 26 Jul. 1982, Columbus Oh. Abstract No. 28542e
Cheng and Prusoff, Biochem. Pharmacol. 22:3099-3108, 1973.
Colvard, et al., Proc. Natl. Acad. Sci. 86: 854-857, 1989.
Deutsch et al., Int. J. Gynecol. Obstet. 25: 217-222, 1987.
Ehrlich et al., Am. J. Obstet Gynecol. 158: 797-807, 1988.
Ericksen et al., Science 241: 84-86, 1988.
Finkelstein et al., J. Clin. Endocr. Metab. 69:776-783, 1989.
Francis, et al., Bone 7: 261-268 (1986).
Foresta et al., Horm. Metab. Res. 15:206-207, 1983.
Foresta et al., Horm. Metab. Res. 15:56-57, 1983.
Goldenberg et al., JAMA 223: 1267-1268, 1973.
Greenspan et al., Ann. Int. Med. 110:526-531, 1989.
Greenspan et al., Ann Int. Med. 104:777-782, 1986.
Haller and Glick, Semin. Oncol. 13: 2-8, 1986.
Hamblen, South Med. J. 50: 743-750, 1987.
Harrison et al., Metabolism 20:1107-1118, 1971.
Hollo et al., Lancet 2:1205, 1971.
Hollo et al., Lancet 1: 1357, 1976.
Hilf. R., Anabolic-Androgenic Steroids and Experimental Tumors In: Handbook of Experimental Pharmacology, vol. 43, Anabolic-Androgenic Steroids, Springer-Verlag, Berlin 43 (1976) 191-210.
Hollo and Feher, Acta. Med. Hung. 20: 233, 1964.
Hollo et al., Acta Med. Hung. 27: 155-160, 1970.
Hortobagyi et al., Breast Cancer Res. Treatm. 5: 321-326, 1985.
Horwitz, J. Steroid Biochem. 27: 447-457, 1987.
Horwitz et al., Cancer Res. 38: 2434-2439, 1978.
Janne and Bardin, Pharmacol. Rev. 36: 35S-42S, 1984.
Johnson et al. Semin. Oncol. 13(suppl):15-19, 1986.
Kennedy et al., Cancer 21: 197-201, 197.
Kennedy, Hormone Therapy in Cancer Geriatrics 25: 106-112, 1970.
Klijn et al., J. Steroid Biochem. 20: 1381, 1984.
Komm, et al., Science 241: 81-84, 1988.
Krabbe et al., Arch. Dis. Child. 54, 950-953, 1979.
Krabbe et al., Arch. Pediat. Scand. 73:750-755, 1984.
Kramer, C. Y., Biometrics 12:307-310, 1956.
Labrie, C. et al., J. Steroid Biochem. 28: 379-384, 1987.
Labrie et al., Fertil Steril 28: 1104-1112, 1977.
Labrie, C., et al., Mol. Cell Endocrinol. 68: 169-179, 1990.
LeMay et al., Fertil. Steril. 31:29-34, 1979.
Lafferty et al., Ann. J. Med. 36: 514-528, 1964.
Lamb, Am. J. Sports Medicine vol. 12 No 1 31-38, 1984.
Lea et al., Cancer Res. 49: 7192-7167, 1989.
Lippman, et al., Cancer Res. 36: 4610-4618, 1976.
Lippman et al., Cancer 38: 868-874, 1976.
Lippman, Semin.

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