Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-10-23
1999-10-26
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530324, 546202, A61K 3800, C07K 1400
Patent
active
059728884
ABSTRACT:
This invention describes methods of treating conditions associated with an excess of neuropeptide Y which comprises administering an obesity protein. This invention also describes methods of treating conditions associated with an excess of neuropeptide Y which comprises administering an obesity protein in combination with a neuropeptide Y antagonist. This invention demonstrates that the obesity protein acts by reducing the production of neuropeptide Y by the hypothalamus.
REFERENCES:
patent: 5569744 (1996-10-01), Basinski et al.
patent: 5614379 (1997-03-01), MacKellar
patent: 5663192 (1997-09-01), Bruns, Jr. et al.
Wahlestedt, C. and Reis, D.J.: Neuropeptide y-related peptides and their receptors-Are the receptors potential therapeutic drug targets?. Annu. Rev. Pharmacol. Toxicol. vol. 32, pp. 309-352, 1993.
Bue-Valleskey Juliana Maude
Heiman Mark Louis
Stephens Thomas Wesley
Tinsley Frank C.
Aulakh Charanjit S.
Eli Lilly and Company
Gaylo Paul J.
Kight John
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