Methods of treating non-insulin dependent diabetes mellitus with

Details Methods of treating non-insulin dependent diabetes mellitus with Methods of treating non-insulin dependent diabetes mellitus with

1997-02-26

1998-11-03

Saunders, David

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Testing efficacy or toxicity of a compound or composition

514 2, 514 4, 514 12, 514 17, 514866, 435810, 530303, 530324, 530329, A61K 4900, A61K 3828, A61K 3808

Patent

active

058304347

ABSTRACT:
The present invention provides a method of treating NIDDM in a patient diagnosed with NIDDM by administering to the patient a compound in a pharmaceutically acceptable carrier that reduces hepatic glucose production in the patient by inhibiting hepatic expression of the alpha subunit of a G.sub.s protein in a liver cell plasma membrane, thereby inhibiting stimulation of cAMP by glucagon, whereby the reduction in hepatic glucose production treats the NIDDM. Also provided is a method for screening compounds for the ability to treat NIDDM comprising determining if the compound decreases hepatic expression of the alpha subunit of a G.sub.s protein in a liver cell plasma membrane, thereby inhibiting the stimulation of cAMP by glucagon, a compound which decreases the hepatic expression of the alpha subunit of the G.sub.s protein in the liver cell plasma membrane, thereby inhibiting the stimulation of cAMP by glucagon, being a compound with the ability to treat NIDDM. The present invention further provides a kit for treating NIDDM comprising a compound in a pharmaceutically acceptable carrier that decreases hepatic expression of the alpha subunit of the G.sub.s protein in the liver cell plasma membrane, thereby inhibiting stimulation of cAMP by glucagon.

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