Methods of treating neurological diseases by regulating...

Details Methods of treating neurological diseases by regulating... Methods of treating neurological diseases by regulating...

2005-03-14

2008-10-07

Ketter, James S (Department: 1636)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S002600, C530S350000

Reexamination Certificate

active

07432251

ABSTRACT:
This invention provides a method for regulating migration of neuronal progenitor cells in the nervous system of a mammal. The method comprises providing a mammal with TNR, a biologically active fragment of TNR, or a TNR agonist in an amount sufficient to direct migration of the neuronal progenitor cells. The invention provides a method of treating neurological diseases by replenishing diseased, damaged, or destroyed neural cells in the central nervous system or in the peripheral nervous system.

REFERENCES:
patent: 2003/0165485 (2003-09-01), Bertilsson et al.
patent: WO 03/039575 (2003-05-01), None
Pasheva, P. et al. The Yin and Yang of Tenascin-R in CNS Development and Pathology, Progress in Neurobiology 61:465-493, 2000.
Ahlskog, J.E. Cerebral Transplantation for Parkinson's Disease: Current Progress and Future Prospects. Mayo Clin. Proc. 68:578-591, 1993.
Freed, W.J. et al. Transplanted Adrenal Chromaffin Cells in Rat Brain Reduce Lesion-Induced Rotational Behavior, Nature 292:351-352, 1981.
Madrazo, I. et al. Open Microsurgical Autograft of Adrenal Medulla to the Right Caudate Nucleus in Two Patients with Intractable Parkinson's Disease, New England Journal of Medicine 361:831-834, 1987.
Eberhardt, O. et al. Gene Therapy in Parkinson's Disease, Cell Tissue Research 318:243-260, 2004.

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