Methods of treating melanomas and gliomas with monoclonal antibo

Details Methods of treating melanomas and gliomas with monoclonal antibo Methods of treating melanomas and gliomas with monoclonal antibo

1994-11-14

1996-09-24

Parr, Margaret

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

4241331, 4241381, 4241551, 4241561, A61K 39395, A61K 3944

Patent

active

055588522

ABSTRACT:
Methods of treating solid or cystic tumors are disclosed. The method comprises administering to a human subject afflicted with a tumor an antibody in a therapeutically effective amount, wherein the antibody is monoclonal antibody Me1-14 or an antibody which binds to the epitope bound by monoclonal antibody Me1-14, and wherein the Fc receptor of the antibody is deleted. When the tumor is a brain tumor, the antibody may be administered by intrathecal injection. If the brain tumor is a cystic brain tumor, and the administering step may be carried out by depositing the antibody in the cyst cavity of the cystic brain tumor. Particularly preferred is a monoclonal antibody Me1-14 F(ab').sub.2 fragment coupled to .sup.131 I.

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