Methods of treating inflammatory bowel diseases by administering

Details Methods of treating inflammatory bowel diseases by administering Methods of treating inflammatory bowel diseases by administering

1998-10-26

2000-10-03

Mertz, Prema

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

424 851, 514 2, 514 8, 514 12, 514885, 514867, A61K 3819

Patent

active

061269336

ABSTRACT:
Provided by the present invention are topical formulations of Interleukin-11 and methods for treating a variety of disorders, including inflammatory bowel diseases (e.g., Crohn's disease, ulcerative colitis, indeterminate colitis, and infectious colitis), mucositis (e.g., oral mucositis, gastrointestinal mucositis, nasal mucositis, and proctitis), necrotizing enterocolitis, inflammatory skin disorders (e.g., psoriasis, atopic dermatitis, and contact hypersensitivity), aphthous ulcers, pharyngitis, esophagitis, peptic ulcers, gingivitis, periodontitis, and ocular diseases (e.g., conjunctivitis, retinitis, and uveitis).

REFERENCES:
patent: 4496537 (1985-01-01), Kwan
patent: 4675183 (1987-06-01), Kato et al.
patent: 5215743 (1993-06-01), Singh et al.
patent: 5215895 (1993-06-01), Bennett et al.
patent: 5236704 (1993-08-01), Fujioka
patent: 5270181 (1993-12-01), McCoy et al.
patent: 5292646 (1994-03-01), McCoy et al.
patent: 5358708 (1994-10-01), Patel
patent: 5371193 (1994-12-01), Bennett et al.
patent: 5700664 (1997-12-01), Yang et al.
Manning, et al., Pharmaceutical Research 6:903-918 (1989).
Hamblin, "Cytokines and Cytokine Receptors," IRL Press, pp. 10, 15, 34, 1993.
Paul et al., PNAS, vol. 87, pp. 7512-7516, 1990.
Cherel et al., Blood, vol. 86(7), pp. 2534-2540, 1995.
Kopf et al., Nature, vol. 36(6464), pp. 339-342, 1994.
Neben et al., Stem Cells (Dayt), vol. 11, Supp. 2, pp. 156-162, Jul. 1993.
Sinkae et al., Jons. Interferon Res., vol. 13 (Suppl. 1), p. S77, 1993.
Pikal, BioPharm, vol. 3, No. 9, pp. 26-30, Oct. 1990.
V. P. Zav'yalov et al., "Theoretical conformational analysis of a family of .alpha.-helical immunocytokines", Biochimica et Biophisica Acta, 1041, pp. 178-185, 1990.
P. Manavalan et al., "Sequence and Structural Relationships in the Cytokine Family", Journal of Protein Chemistry, vol. 11, No. 3, 1992.
A. G. Bruce et al., "ONCOSTATIN M", Progress in Growth Factor Research, vol. 4, pp. 157-170, 1992.
E. Minasian et al., "A review of cytokine structure", Protein Seq. Data Anal., vol. 5, pp. 57-64, 1992.
W. Strober et al., "The Interleukins", Pediatric Research, vol. 24, No. 5, pp. 549-557, 1988.
J.P. Leonard et al., J.Exp.Med 181:381-386 (1995).
R.H. Scofield et al., PNAS 90:9330-9334 (1993).
R.E. Hammer et al., Cell 63:1099-1112 (1990).
Sonis, et al., Proceedings of the American Assoc. for Cancer Research 36:368 (1995) (abstract 2190).
Keith, Jr. et al., Gastroenterology 108(4):A846 (1995) (abstract).
Keith, Jr. et al., Gastroenterology 106(4):A708 (1994) (abstract).
Keith, Jr. et al., Stem Cells 12(S1):79-90 (1994).
Opal, et al., Blood 86(10):498A (1995) (abstract).
Sonis, et al., European Journal of Cancer, Part B, Oral Oncology 31B(4):261-266 (1995).
M. Feldmann et al., "Role of Cytokines in Rheumatoid Arthritis", Annu. Rev. Immunol., vol. 14, pp. 397-440, 1996.
G. Girasole et al., "Interleukin-11, A New Cytokine Critical for Osteoclast Development", The Journal of Clinical Investigation, Inc., vol. 93, pp. 1515-1524, 1994.
W. E. Paul in: "Fundamental Immunology", Editor, W. E. Paul, Publisher, Raven Press, 1996, New York.
F. M. Brennan, "Role of cytokines in experimental arthritis", Clin. Exp. Immunol., 97:1-13, 1994.
Wang et al., "Parenteral Formulations of Proteins and Peptides: Stability and Stabilizers", J. Of Parenteral Sci and Tech, vol. 6(1), pp. 902-918, 1989.

Affiliated with

Also associated with

Rating

Methods of treating inflammatory bowel diseases by administering does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of treating inflammatory bowel diseases by administering, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of treating inflammatory bowel diseases by administering will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-192311