Methods of treating inflammatory and/or autoimmune disease

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

Reexamination Certificate

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C424S184100, C424S185100, C424S085200, C514S012200

Reexamination Certificate

active

10991812

ABSTRACT:
The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, the use of such polypeptides in cellular and immune reactions, the use of such polypeptides in screening for agonists or antagonists of IL-1 epsilon activity, and kits comprising such polypeptides.

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patent: WO99/37662 (1999-07-01), None
Database EMBL. Entry MMA30324, Accession No. AA030324, Jan. 21, 1997, 2125184, Marra et al.
Dinarello, C.A., “Interleukin-1,”Cytokine and Growth Factor Reviewvol. 8(4):253-265.
Bowie J.U. et al., “Deciphering the message in protein sequence tolerance to amino acid substitutions,”Science247:1306-1310, 1990.
Geysen H.M. et al., “Cognitive features of continuous antigenic determinants,”J Mol Recognit1:32-41, 1988.
Colman P.M., “Effects of amino acid sequence changes on antibody-antigen interactions,”Research in Immunology145:33-36, 1994.
Dinarello, C.A., “Interleukin-1,”Cytokine and Growth Factor Reviewvol. 8(4):253-265, 1997.

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