Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1995-06-06
1999-06-29
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
514 21, A61K 3816
Patent
active
059170140
ABSTRACT:
Compositions and methods for treating inflammatory cell infiltration in a tissue of a mammalian subject are provided. The method involves administering a therapeutically effective amount of SERP-1, SERP-1 analog or biologically active fragment thereof admixed with a pharmaceutically acceptable carrier to a subject in need of such treatment. Biologically active SERP-1 analogs are also provided. The compositions and methods of the present invention are useful for treating numerous inflammatory based diseases and injuries.
REFERENCES:
McFadden, "Myxoma Virus Encode a Serpin-Like Protein" Virology, v. 169, pp. 618-631 (1991).
Upton et al., "DNA Seq Homology of Shope Fibroma Virus" Molec. & Cellular Biol., v. 6, n. 1, pp. 265-276 (1986).
Upton, "Novel Member of Serpin Superfamily" F.E.B.S., v. 207, n. 1, pp. 115-120 (1986).
Macen et al. "SERP1, Secreted Glycoprotein That Interferes with Inflammation", Virology, v. 195, pp. 348-363 (1993).
Lange "Review of Medical Physiology" 17th Edition (1995) Simon & Schuster, pp. 484-485.
Fukusen, et al. (Jan. 8, 1987) "Kinetic Studies on the Inhibitions of Mast Cell Chymase by Natural Serine Protease Inhibitors: Indications for Potential Biological Functions of these Inhibitors" Biochemical Medicine and MetabolicBiology 38:165-169.
Lucas Alexandra
McFadden D. Grant
Delaney Patrick R.
Tsang Cecilia J.
Viron Therapeutics Inc.
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