Methods of treating hypertension

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

active

07820667

ABSTRACT:
It is an object of the present invention to provide a therapeutic agent for effectively preventing or ameliorating diseases caused by dysfunction of NOS.The present invention provides a pharmaceutical composition for preventing and/or treating diseases associated with dysfunction of NOS, comprising as an effective ingredient, a compound of the formula (I):wherein R1and R2each represents a hydrogen atom or, taken together with each other, represent a single bond, while R3represents —CH(OH)CH(OH)CH3, —CH(OCOCH3)CH(OCOCH3)CH3, —CH3, —CH2OH, or a phenyl group when R1and R2each represents a hydrogen atom, or —COCH(OH)CH3when R1and R2together represent a single bond, or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 5196533 (1993-03-01), Ayling et al.
patent: 6288067 (2001-09-01), Okamura et al.
patent: 0722731 (1996-07-01), None
patent: 59-25323 (1984-02-01), None
patent: 59-76086 (1984-04-01), None
patent: 61-277618 (1986-12-01), None
patent: 63-267781 (1988-11-01), None
patent: 7188024 (1995-07-01), None
patent: 07188233 (1995-07-01), None
patent: WO 95/32203 (1995-05-01), None
patent: WO98/08516 (1998-03-01), None
Cosentio et al., Circulation, 91(1), (1995), 139-144.
West et al., Journal of Endocrinology, (135, Suppl., p. 62, 1992) (abstract).
Kukor et al., Placenta, (Jan. 1996), 17(1), pp. 69-73.
Shintaku et al., Chemistry and Biology of Pteridines and Folates (Jun. 1997), Proceedings of the International Symposium of Pteridines and Folates, pp. 765-769.
Ishihara et al., Archives of Biochemistry and Biophysics, 298(2), pp. 726-730 (abstract), 1992.
Sheng et al., J. Neurochem., 61(3), 1120-6 (abstract), 1993.
Van Amsterdam J.G. and Werner, J. “Tetrahydrobiopterin induces . . . cGMP level” 1992 Eur. J. Pharmacol. vol. 215, pp. 349-350 (abstract).
Fukushima et al., “Analysis of Reduced Forms of Biopterin In Biological Tissues and Fluids”, Analytical Biochemistry, 102, 1980, pp. 176-188.
Ujiie et al., “Localization and Regulation of Endothelial NO Synthase mRNA Expression in Rat Kidney”, American J. Physiol., 267, 1994, pp. F296-F302.
Hirata et al., “Direct Measurements of Endothelium-Derived Nitric Oxide Release by Stimilation of Endothelin Receptors in Rat Kidney and Its Alteration in Salt-Induced Hypertension”, Circulation, vol. 91, No. 4, 1995, pp. 1229-1235.
Hayakawa et al., “Long-term Administration of L-Arginine Improves Nitric Oxide Release From Kidney in Deoxycorticosterone Acetate-Salt Hypertensive Rats”, Hypertension. vol. 23, No. 6, Part 1, 1994, pp. 752-756.
Rector et al., “Randomized, Double-Blind, Placebo-Controlled Study of Supplemental Oral L-Arginine in Patients With Heart Failure”, Circulation, vol. 93, No. 12, 1996, pp. 2135-2141.
Egashira et al., “Effects of L-Arginine Supplementation on Endothelium-Dependent Coronary Vasodilation in Patients With Angina Pectoris and Normal Coronary Arteriograms”, Circulation, vol. 94, No. 2, 1996, pp. 130-134.
Ishihara et al. Archives of Biochemisty and Biophysics, 298(2), pp. 726-730 (abstract).
Sheng et al., J. Neurochem., 61(3), 1120-6 (abstract).
Biochemical and Biophysical Research Communications, vol. 215, No. 3, pp. 1119-1129, (1995); Pei-Feng Chen et al. “Cysteine 99 of Endothelial Nitric Oxide Synthase (Nos-III) is Critical For Tetrahydrobiopterin-Dependent Nos-III Stability and Activity”.
Journal of Cardiovascular Pharmacology, vol. 26, No. 6, pp. 916-922 (1995); Voker Vallon et al. “Interactive Control of Renal Function by a2-Adrenergic System and Nitric Oxide: Role of Angiotensin II”.
Science, vol. 272, No. 5262, pp. 689-693, (1996) Gary H. et al. “Molecular Therapies for Vascular Diseases”.
Laboratory Investigation, vol. 72, No. 1, pp. 17-24 (1995) Ichiei Narita et al. “Nitric Oxide Mediates Immunologic Injury to Kidney Mesangium In Experimental Glomerulonephritis.”
Ann. Med., vol. 27, No. 3, pp. 353-7, (1995) Tikkanen, Iikka et al. “Nitric Oxide in Hypertension and Renal Diseases”.
Baker et al. “Plasma From Women With Preeclampsia Increases Endothelial Cell Nitric Oxide Production” Hypertension. 1995, 26, pp. 244-248.
Davidge et al. “NOS expression is increased in endothelial cells exposed to plasma from women with preeclampsia” J. Physiol. Sep. 1995, 268(3 Pt 1):H1 106-12.
Silver et al. “Evaluation of nitric oxide as a mediator of severe preeclampsia” Am. J. Obste. Gynecol. Oct. 1996, 175(4 Pt 1):1013-7.
Scott-Burden, T., “Regulation of Nitric Oxide Production by Tetrahydrobiopterin”, Circulation, vol. 91, 1995, pp. 248-250.
Yamamoto et al, “A Comparison of Seplapterin and Tetrahydrobiopterin Uptake by BRL2H3 Cells,” Pteridlnes, vol. 7, 1996, 154-156.
Yaoka et al, “Antihypertensive activity of the angiotensin . . . in various hypertensive animal models,” Nippon Yakugaku Zasshi, 1993, 102(1): 35-45 (PubMed abstract only).
Yamamoto et al, “Pharmacological profile of valsartin, . . . effects of valsartan in hypertensive models,” Arznelittelforschung, 1997, 47(5): 604-612 (PubMed abstract only).
Nava et al, “Alterations to the nitric oxide pathway in the spontaneously hypertensive rat,” J Hypertension, 1998, 16(5): 609-615.
Kulper et al, “Decreased cerebrospinal fluid nitrate levels in Parkinson's Disease, . . . and multiple system atrophy patients,” Journal of the Neurological Sciences, 121(1994) 46-49.
Brand et al, “Tetrahydrobiopterin deficiency and brain nitric oxide synthase I the hph1 mouse,” J Inherit Metab Dis, 1995, 18(1), 33-39.
Meininger et al., impaired nitric oxide production . . . due to tetrahydrobiopterin deficiency, Biochem J. (2000) 349, 353-356.
Fortepiani and Reckelhoff, “Treatment with tetrahydrobiopterin . . . testosterone synthesis,”Amer. J. Physiol. Regul. Integr. Comp. Physiol. 288:733-736 (2005) (first published Dec. 2004).
Vasques-Vivar et al., “The ratio between tetrahydrobioprterin . . . spin trapping study,” Biochem. J. 362: 733-739 (2002).
Channon, K., “Tetrahydrobiopterin, Regulator of Endothelial . . . Vascular Disease,” Trends Cardiovasc. Med 14:323-327 (2004).
Kinoshita et al., “Exogenous tetrahydrobiopterin . . . canine basilar artery,” Am J Physiol. (Aug. 1996); 271(2 Pt 2): H738-43.
Rosenkranz-Weiss et al., “Regulation of Nitric Oxide . . . Umbilical Vein Endothelial Cells,” J. Clin. Invert. 93:2236-2243 (1994).
Van Amsterdam et al., “Tetrahydrobiopterin induces vasodilatation via enhancement of cGMP level,” Eur. J. Pharmacol. 215:349-350 (1992).
Lefever et al. 2003 Scientific Sessions of the American Heart Association, Nov. 9-12, 2003, Orlando, Florida, USA: Clinical Pathophysiology of Hypertension, Presentation No. AOP.43.3: 2378,[Published in Circulation, Oct. 28, 2003; 108(17 Suppl):IV1-7870].
Porkert et at., American College of Cardiology ACC.06, Atlanta, Georgia, Mar. 14, Poster Session, Session No. 1027, Presentation No. 1027-194(2006).
BioMarin Pharmaceutical Inc. (Novato, California, Feb. 20, 2007). BioMarin Announces Results from Phase 2 Clinical Study of 6R-BH4 in Poorly Controlled Hypertension. Press Release.
Pinto et al., “Lessons from rat models of hypertension: from Goldblatt to genetic engineering” Cardiovasc Res. Jul. 1988;39(1):77-88.
Mellouk, Sylvie et al. “Nitric Oxide-Mediated Antiplasmodial Activity in Human . . . Exogenous Tetrahydrobiopterin” Infection and Immunity, Sep. 1994, pp. 4043-4046.
Klatt, Peter, et al. “The Pteridine Binding Site of Brain Nitric Oxide Synthase” J. of Biological Chemistry, vol. 269, No. 19, May 13, 1994, pp. 13861-13866.
Kerwin, James et al., “Nitric Oxide: A New Paradigm for Second Messengers” J. Of Medicinal Chemistry, vol. 38, No. 22, Oct. 27, 1995, pp. 4343-4362.
Martasek et al. “Characterization of Bovine Endothelial Nitric Ox

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