Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Reexamination Certificate
2005-06-14
2005-06-14
Gambel, Phillip (Department: 1644)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
C424S130100, C424S141100, C424S143100, C424S144100, C424S153100, C424S154100, C424S173100, C424S093700, C424S534000, C424S577000, C424S578000, C435S002000, C435S007100, C435S007210, C435S007240, C435S375000, C435S377000, C530S387100, C530S388100, C530S388200, C530S388220, C530S388700, C530S388730, C530S388750
Reexamination Certificate
active
06905680
ABSTRACT:
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.
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Gray Gary S.
June Carl H.
Nabel Gary J.
Rennert Paul D.
Thompson Craig B.
Gambel Phillip
Genetics Institute Inc.
Regents of the University of Michigan
The United States of America as represented by the Secretary of
Wilmer Cutler Pickering Hale and Dorr LLP
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