Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2008-03-25
2008-03-25
Crane, L. E. (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C536S026260
Reexamination Certificate
active
10396200
ABSTRACT:
Disclosed herein are methods of using an adenosine analog or derivative for treating heart failure, increasing cardiac muscle contractility, increasing cardiac diastolic relaxation, and increasing vasodilation. Exemplary adenosine analogs/derivatives include compounds of the following formulawhereinL is CH or O, wherein when L is CH, t is 1 and when L is O, t is 0;R1is halogen or —R6—(R7)p—R8;R2is hydrogen, alkyl, cycloalkyl, cycloalkenyl, alkynyl, alkylthio, aminoalkylthio, halogen, or —R6—(R7)p—R8;R3is H, halogen or —R6—(R7)p—R8;R4is —OH or —SH;R5is —OH or —R6—(R7)p—R8;R6is NH or S;R7is CH2;R8is H, NH2, halogen, CN, CCH, cycloallkyl, having 3 to about 10 carbon atoms or aryl having 3 to about 20 carbon atoms;R9is OH or acetamido;R10and R11are independently hydrogen or halogen;X, Y, and Z are independently N or CH;m is 0, 1, or 2;n is 0 or 1;q is 0 or 1 if L is CH, or if L is O, R3is halogen or —R6—(R7)p—R8;q is 1 if L is O, R3is H, halogen, or —R6—(R7)p—R8;provided that at least one of m, n, and q is 1; andp is 0 to 10.
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Jacobson Kenneth A
Liang Bruce T
Cantor & Colburn LLP
Crane L. E.
The University of Connecticut
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