Methods of treating granulocyte-macrophage progenitor cell-deriv

Details Methods of treating granulocyte-macrophage progenitor cell-deriv Methods of treating granulocyte-macrophage progenitor cell-deriv

1995-06-07

1999-08-24

Allen, Marianne P.

Drug, bio-affecting and body treating compositions

Lymphokine

530351, 514 12, A61K 3819

Patent

active

059422220

ABSTRACT:
The present invention relates to the identification of promoters of myelopoietic blood cell production. In particular, an agent has been discovered that enhances myelopoietic colony stimulating factor activity. The agent comprises cytokines that are also capable of binding to heparin, and inducing localized inflammation characterized by polymorphonuclear cell infiltration when administered subcutaneously. Particular agents comprise the inflammatory cytokines MIP-1 and MIP-2. Diagnostic and therapeutic utilities are proposed, and pharmaceutical compositions are likewise set forth.

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