Methods of treating diseases caused by deficiencies of...

Details Methods of treating diseases caused by deficiencies of... Methods of treating diseases caused by deficiencies of...

2008-04-08

2008-04-08

Prouty, Rebecca (Department: 1652)

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

C435S200000, C536S023200

Reexamination Certificate

active

10895011

ABSTRACT:
The present invention provides a formulation comprising a pharmaceutical composition comprising a human recombinant α-L-iduronidase or biologically active or muteins thereof with a purity of greater than 99%, or in combination with a pharmaceutically acceptable carrier. The present invention further provides methods to treat certain genetic disorders including α-L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1) by administering said formulation.

REFERENCES:
patent: 6585971 (2003-07-01), Kakkis
patent: 6858206 (2005-02-01), Kakkis
patent: 7041487 (2006-05-01), Kakkis et al.
patent: 2005/0048047 (2005-03-01), Kakkis
patent: 2005/0260185 (2005-11-01), Kakkis
patent: 2006/0286087 (2006-12-01), Kakkis et al.

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