Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Patent
1995-04-13
1998-03-10
Wityshyn, Michael G.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
4352401, A01N 6300, C12N 500
Patent
active
057258546
ABSTRACT:
The present invention describes a method of treating a disease that results from a deficiency of a biological factor which includes administering to a mammal Sertoli cells and cells that produce the biological factor. In particular, the present invention describes a method of treating diabetes mellitus by transplanting pancreatic islet of Langerhans cells in conjunction with Sertoli cells to create an immunologically privileged site. A method of creating an immunologically privileged site in a mammal for cellular transplants is further described by the present invention. A pharmaceutical composition comprising Sertoli cells and cells that produce a biological factor is also provided.
REFERENCES:
Selawry et al., (1988) "Intratesticular Islet Xenograft Survival in Relation to Tissue Cyclosporine Levels", The American Journal of Medical Science, 295(6): 497-502.
Whittington et al., (1991) "Islet Allografts in the Cryptorchid Test of Spontaneously Diabetic BB/W or dp Rats: Response to Glucose, Glipizide, and Arginine", Endo. 128(6): 2671-2677.
Tze et al., (1990) "Human Islet Xenograft Survival in Diabetics Rats", Transplantation, 43(3): 502-505.
Korsgren et al., (1993) "Pancreatic Islet Transplantation in the Human", Advances in Nephrology, 22: 371-387.
Barker et al., (1991) "Studies of Privileged Sites and Islet Transplantation", Transplantation Proceedings, 23:(4) 2138-2142.
Cameron et al., (1990) "Successful Islet Abdominal Testis Transplantation Does Not Require Leydig Cell", Transplantation, 50:(4) 649-653.
Groth et al., (1994) "Transplantation of Porcine Fetal Pancreas to Diabetic Patients", Lancet, 344: 1402-04.
Selawry et al., (1994) "Extended Functional Survival of Abdominal Intratesticular Islet Alografts in Rhesus-Monkeys", Diabetes, 43: PA162.
Selawry et al., (1989) "Abdominal Intratesticular Islet-Xenograft Survival in Rats", Diabetes, 38:(1) 220-223.
Soon-Shiong et al., (1993) "Long-Term Reversal of Diabetes by the Injection of Immunoprotected Islets",Proc. Nat'l Acad. Sci. USA, 90: 5843-5847.
Soon-Shiong et al., (1994) "Insulin Independence in a Type 1 Diabetic Patient After Encapsulated Islet Transplantation", Lancet, 343: 950-951.
Tze, et al., (1992) "Transplantation of Discordant Pig Islet Xenografts in Diabetic Rats", Diabetes Research and Clinical Practice, 15: 197-204.
Tze et al., (1993) "Diabetic Rabbit Model For Pig Islet Xenotransplantation", Transplantation, 56:(6) 1348-1352.
Tze et al., (1994) "Prolongation of Pig Islet Xenograft in Rats By Local Immunosuppression with FK 506", Transplantation Proceedings, 26:(2) 777-778.
Selawry et al., (1993) "Sertoli Cell-Enriched Fractions in Successful Islet Cell Transplantation", Cell Transplantation, 2: 123-129.
Dahaney, D.G., (Jul., 1991), "A biochemical and immunohistochemical study of rat Sertoli cells", Chemical Abstracts 115(3): 26534-26535.
Hutson et al. (Mar., 1993), "Sertoli cell function in diabetic, insulin-treated diabetic, and semi-starved rats", Chemical Abstracts 98(13): 105350-105351.
Selawry, et al. (Nov. 1991) "Production of a Factor, or Factors, Suppressing IL-2 Production and T Cell Proliferation by Sertoli Cell-Enriched Preparations. A Potential Role for Islet Transplantation in an Immunologically Privileged Site", Transplantation 52(5): 846-850.
Oonk, et al. (1988) "Insulin-Like Growth Factor I (IGF-I) Receptors on Steroli Cells from Immature Rats and Age-Dependent Testicular Binding of IGF-I and Insulin", Molecular and Cellular Endocrinology 55:33-43.
Whitmore III, et al. (Oct. 1985) "The Role of Germinal Epithelium and Spermatogenesis in the Privileged Survival Intratesticular Grafts", The Journal of Urology 134(4): 782-786.
Hofmann, et al. (Aug. 1992), Abstract No. 92347475 "Immortalization of Germ Cells and Somatic Testicular Cells Using the SV40 Large T Antigen", Experimental Cell Research 201(2): 417-435.
Lejeune, et al. (1993), Abstract No. 93:280614 "Enhancement of Testosterone Secretion by Normal Adult Human Leydig Cells b Co-Culture with Enriched Preparations of Normal Adult Human Sertoli Cells", Int. J. Androl. 16(1): 27-34.
Berends, et al. (1991), Abstract No. 92:167853 "Significant Improvement of the Survival of Seminoma Cells in vitro by use of a Rat Sertoli Cell Feeder Layer and Serum-Free Medium", J. Natl. Cancer Inst. 83(19):1400-1403.
Research Corporation Technologies Inc.
Ware Deborah
Wityshyn Michael G.
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