Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-12-27
1998-10-06
Prats, Francisco C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 25, 514 54, 514 61, 514866, 536 41, 536 186, 5361231, 53612313, 536123, 536 172, 25217417, A61K 3170, A61K 31705, C07H 702
Patent
active
058176349
ABSTRACT:
This present invention provides a method and compounds for priming the incorporation of cellular glucose into an oligosaccharide in a cell comprising administering to the cell a priming amount of a membrane-permeating nontoxic glycoside having a suitable hydrophobic organic group joined by a linkage to a suitable hydrophilic saccharide, wherein the hydrophilic saccharide has a nonreducing terminal sugar residue selected from the group consisting of glucose or xylose, thereby priming the incorporation of cellular glucose onto the glycoside to form an oligosaccharide. Also disclosed are methods wherein the administration of the glycoside is sufficient to treat diabetes mellitus and glycogen storage disease.
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Manzella Stephen M.
Meezan Elias
Adler, I.D. Benjamin Aaron
Prats Francisco C.
The UAB Research Foundation
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