Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2011-08-23
2011-08-23
Weddington, Kevin E (Department: 1629)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S078000, C514S231200, C514S233800, C514S236200, C514S380000, C514S422000, C514S428000, C514S561000, C514S625000, C514S629000, C514S635000, C514S866000
Reexamination Certificate
active
08003617
ABSTRACT:
The invention provides methods of treating a diabetic subject comprising administering a glucosylceramide synthase inhibitor to the subject.
REFERENCES:
patent: 4065562 (1977-12-01), Ohata et al.
patent: 4182767 (1980-01-01), Murai et al.
patent: 4533668 (1985-08-01), Matsumura et al.
patent: 4639436 (1987-01-01), Junge et al.
patent: 5041441 (1991-08-01), Radin et al.
patent: 5302609 (1994-04-01), Shayman et al.
patent: 5472969 (1995-12-01), Platt et al.
patent: 5525616 (1996-06-01), Platt et al.
patent: 5631394 (1997-05-01), Wei et al.
patent: 5707649 (1998-01-01), Inokuchi et al.
patent: 5763438 (1998-06-01), Inokuchi et al.
patent: 5849326 (1998-12-01), Inokuchi et al.
patent: 5907039 (1999-05-01), Jinbo et al.
patent: 5916911 (1999-06-01), Shayman et al.
patent: 5945442 (1999-08-01), Shayman et al.
patent: 5952370 (1999-09-01), Shayman et al.
patent: 5972928 (1999-10-01), Chatterjee
patent: 6030995 (2000-02-01), Shayman et al.
patent: 6040332 (2000-03-01), Shayman et al.
patent: 6051598 (2000-04-01), Shayman et al.
patent: 6228889 (2001-05-01), Chatterjee
patent: 6255336 (2001-07-01), Shayman et al.
patent: 6335444 (2002-01-01), Jinbo et al.
patent: 6511979 (2003-01-01), Chatterjee
patent: 6569889 (2003-05-01), Shayman et al.
patent: 6610703 (2003-08-01), Jacob et al.
patent: 6660749 (2003-12-01), Butters et al.
patent: 6835831 (2004-12-01), Hirth
patent: 6855830 (2005-02-01), Hirth et al.
patent: 6890949 (2005-05-01), Shayman et al.
patent: 6916802 (2005-07-01), Shayman et al.
patent: 7148251 (2006-12-01), Shayman
patent: 7196205 (2007-03-01), Siegel et al.
patent: 7253185 (2007-08-01), Shayman et al.
patent: 7265228 (2007-09-01), Hirth et al.
patent: 7335681 (2008-02-01), Shayman et al.
patent: 2001/0003741 (2001-06-01), Masuda et al.
patent: 2002/0156107 (2002-10-01), Shayman et al.
patent: 2002/0198240 (2002-12-01), Shayman et al.
patent: 2003/0050299 (2003-03-01), Hirth et al.
patent: 2003/0073680 (2003-04-01), Shayman et al.
patent: 2004/0260099 (2004-12-01), Shayman
patent: 2005/0009872 (2005-01-01), Hirth et al.
patent: 2005/0049235 (2005-03-01), Shayman et al.
patent: 2005/0222244 (2005-10-01), Siegel et al.
patent: 2005/0239862 (2005-10-01), Shayman et al.
patent: 2005/0267094 (2005-12-01), Shayman et al.
patent: 2006/0058349 (2006-03-01), Ali et al.
patent: 2006/0074107 (2006-04-01), Butters et al.
patent: 2006/0217560 (2006-09-01), Shayman
patent: 2007/0066581 (2007-03-01), Aerts
patent: 2007/0072916 (2007-03-01), Shayman
patent: 2007/0112028 (2007-05-01), Orchard
patent: 2007/0203223 (2007-08-01), Siegel et al.
patent: 2008/0146533 (2008-06-01), Shayman et al.
patent: 2009/0312392 (2009-12-01), Shayman et al.
patent: 2010/0256216 (2010-10-01), Siegel et al.
patent: 0126974 (1984-12-01), None
patent: 0 144 290 (1985-06-01), None
patent: 1 384 719 (2004-01-01), None
patent: 1 528 056 (2005-05-01), None
patent: 1576894 (2005-09-01), None
patent: 2054371 (1981-02-01), None
patent: 35-5798 (1960-05-01), None
patent: 9-169664 (1997-06-01), None
patent: 9216856 (1997-08-01), None
patent: 10-324671 (1998-12-01), None
patent: 10338636 (1998-12-01), None
patent: 2003 238410 (2003-08-01), None
patent: WO 97/10817 (1997-03-01), None
patent: WO 98/52553 (1998-11-01), None
patent: WO 01/04108 (2001-01-01), None
patent: WO 01/80852 (2001-11-01), None
patent: WO 02/50019 (2002-06-01), None
patent: WO 02/055498 (2002-07-01), None
patent: WO 02/062777 (2002-08-01), None
patent: WO 03/008399 (2003-01-01), None
patent: WO 03/057874 (2003-07-01), None
patent: WO 03/068255 (2003-08-01), None
patent: WO 2004/007453 (2004-01-01), None
patent: WO 2004056748 (2004-07-01), None
patent: WO 2004/078193 (2004-09-01), None
patent: WO 2005/039578 (2005-05-01), None
patent: WO 2005/040118 (2005-05-01), None
patent: WO 2005/063275 (2005-07-01), None
patent: WO 2005087023 (2005-09-01), None
patent: WO 2005/108600 (2005-11-01), None
patent: WO 2005/123055 (2005-12-01), None
patent: WO 2006/053043 (2006-05-01), None
patent: WO 2006/053043 (2006-05-01), None
patent: WO 2007/022518 (2007-02-01), None
patent: WO 2007/134086 (2007-11-01), None
patent: WO 2007/134086 (2007-11-01), None
patent: WO 2008/011478 (2008-01-01), None
patent: WO 2008/011487 (2008-01-01), None
patent: WO 2008/012555 (2008-01-01), None
patent: WO 2008/150486 (2008-12-01), None
patent: WO 2009/045503 (2009-04-01), None
patent: WO 2009/117150 (2009-09-01), None
International Search Report and Written Opinion for PCT/US2005/0405967, mailed Jun. 27, 2006 from the International Searching Authority of the European Patent Office.
Jimbo et al., “Development of a New Inhibitor of Glucosylceramide Synthase1,” J. Biochem 127:485-491, 2000.
Lee et al., “Improved Inhibitors of Glucosylceramide Synthase,” J. Bio. Chem. 274:14662-14669, 1999.
Seibutsu Yuki Kagaku Kenkyusho KK, Database Accession No. XP-002372073, Derwent Publications Ltd., Aug. 27, 2003.
Jankowski, K., “Microdetermination of phosphorus in organic materials from polymer industry by microwave-induced plasma atomic emission spectrometry after microwave digestion”,Microchem. J., 70:41-49, 2001.
International Preliminary Report on Patentability for International Application No. PCT/US2008/011450 dated Apr. 7, 2010.
International Preliminary Report on Patentability for International Application No. PCT/US2009/001773 dated Sep. 21, 2010.
Abe, A., et al., “Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth,”J. of Lipid Research, 36:611-621 (1995).
Abe, A., et al., “Induction of Glucosylceramide Synthase by Synthase Inhibitors and Ceramide,”Biochim. Biophys. Acta, 1299: 333-341 (1996).
Abe, A., et al., “Metabolic Effects of Short-Chain Ceramide and Glucosylceramide on Sphingolipids and Protein Kinase C,”Eur. J. Biochem, 210: 765-773 (1992).
Abe, A., et al., “Improved Inhibitors of Glucosylceramide Synthase,”J. Biochem., 111:191-196 (1992).
Abdel-Magid, A., et al., “Metal-Assisted Aldol Condensation of Chiral α-Halogenated Imide Enolates: A Stereocontrolled Chiral Epoxide Syntheses,”J. Am. Chem Soc., 108: 4595-4602 (1986).
Adams, L.A., et al., “Nonalcoholic Fatty Liver Disease,”CMAJ, 172(7):899-905 (2005).
Alberti, C., “Chloramphenicol. XII and XIII. Chloramphenicol analogs. p-Nitrophenyldiaminopropanols”,Chemical Abstracts Service, XP002495477 retrieved from CAPLUS Database accession No. 1957:17088 (abstract).
Alker, D., et al., “Application of Enantiopure Templated Azomethine Ylids to β-Hydroxy-α-amino Acid Syntheses,”Tetrahedron, 54: 6089-6098 (1998).
Alon, R., et al., “Glycolipid Ligands for Selectins Support Leukocyte Tethering and Rolling Under Physiologic Flow Conditions,”J. Immunol., 154: 5356-5366 (1995).
Ames, Bruce N., “Assay of Inorganic Phosphate, Total Phosphate and Phosphatases,”Methods Enzymol., 8: 115-118 (1996).
Asano, N., “Glycosidase Inhibitors: Update and Perspectives on Practical Use,”Glycobiology, 13(10):93R-104R (2003).
Bielawska, A., et al., “Ceramide-Mediated Biology: Determination of Structural and Stereospecific Requirements Through the Use ofN-Acyl-Phenylaminoalcohol Analogs,”J. Biol. Chem., 267: 18493-18497 (1992).
Bielawska, et al., “Modulation of Cell Growth and Differentiation by Ceramide,”FEBS Letters, 307(2): 211-214 (1992).
Blobe, G.C., et al., “Regulation of Protein Kinase C and its Role in Cancer Biology,”Cancer Metastasis Rev., 13: 411-431 (1994).
Brenkert, A., et al., “Synthesis of Galactosyl Ceramide and Glucosyl Ceramide by Rat Brain: Assay Procedures and Changes with Age,”Brain Res., 36: 183-193 (1972).
Caplus Listing of Accession No: 1985:221199, Keith McCullagh, et al., “Carboxyalkyl peptide derivatives.”
Carson, K.G., et al., “Studies on Morpholinosphingolipids: Potent Inhibitors of Glucosylceramide Synthase,”Tetrahedron Letters, 35(17): 2659-2662 (1994).
Chatterjee, S., et al., “O
Cheng Seng H.
Scheule Ronald K.
Yew Nelson S.
Zhao Hongmei
Genzyme Corporation
Hamilton Brook Smith & Reynolds P.C.
Weddington Kevin E
LandOfFree
Methods of treating diabetes mellitus does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of treating diabetes mellitus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of treating diabetes mellitus will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2717911