Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2008-05-23
2010-11-16
Robinson, Hope A (Department: 1652)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S012200, C514S002600, C530S350000, C530S300000, C530S396000
Reexamination Certificate
active
07833982
ABSTRACT:
Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an effective amount of an agonist of the non-proteolytically activated thrombin receptor.
REFERENCES:
patent: 5352664 (1994-10-01), Carney et al.
patent: 5500412 (1996-03-01), Carney et al.
patent: 7049294 (2006-05-01), Carney
patent: 7378500 (2008-05-01), Carney
patent: WO 88/03151 (1988-05-01), None
patent: WO 96/40033 (1996-12-01), None
patent: WO 01/49309 (2001-07-01), None
Stiernberg, J., et al., “Acceleration of full-thickness wound healing in normal rats by the synthetic thrombin peptide, TP508,”Wound Repair and Regeneration, 8(3):204-215 (May-Jun. 2000).
Norfleet, A.M., et al., “Thrombin peptide, TP508, stimulates angiogenic responses in animal models of dermal wound healing, in chick chorioallantoic membranes, and in cultured human aortic and microvascular endothelial cells,”General Pharmacology, 35:249-254 (Nov. 2002).
Norfleet, A.M., et al., “Thrombin peptide TP508 accelerates closure of dermal excisions in animal tissue with surgically induced ischemia,”Wound Repair and Regeneration, 8(6):517-529 (Nov.-Dec. 2000).
Pernia, S.D., et al., “A Synthetic Peptide Representing the Thrombin Receptor-Binding Domain Enhances Wound Closure In Vivo,”SAAS Bulletin: Biochem.&Biotech., 3:8-12 (1990).
Carney, Darrell H., “Postclotting Cellular Effects of Thrombin Mediated by Interaction with High-Affinity Thrombin Receptors,” InThrombin Structure and Function, Berliner, L.J. (ed.) (New York: Plenum Press), pp. 351-396 (1992).
Stiernberg, J., et al., “The Role of Thrombin and Thrombin Receptor Activating Peptide (TRAP-508) in Initiation of Tissue Repair,”Thrombosis and Haemostasis,70(1)158-162 (1993).
Carney, D.H., et al., “Enhancement of Incisional Wound Healing and Neovascularization in Normal Rats by Thrombin and Synthetic Thrombin Receptor-activating Peptides,”J Clin. Invest., 89:1469-1477 (1992).
Carney, D.H., et al., “Role of High-Affinity Thrombin Receptors in Postclotting Cellular Effects of Thrombin,”Seminars in Thrombosis and Hemostasis, 18(1):91-102 (1992).
Glenn, K.C., et al., “Synthetic Peptides Bind to High-Affinity Thrombin Receptors and Modulate Thrombin Mitogenesis,”Peptide Research, 1(2):65-73 (1988).
Sower, L.E., et al., “Thrombin Peptide, TP508, Induces Differential Gene Expression in Fibroblasts through a Nonproteolytic Activation Pathway,”Experimental Cell Research, 247:422-431 (1999).
Steed, D.L., et al., “Promotion and Acceleration of Diabetic Ulcer Healing by Arginine-Glycine-Aspartic Acid (RGD) Peptide Matrix,”Diabetes Care, 18(1):39-46 (1995).
Press Release: Chrysalis BioTechnology to begin clinical trials, (Sep. 24, 1998).
Press Release: Chrysalis Announces Completion of Pilot Chrysalin® Clinical Trial for Diabetic Ulcers, (Aug. 21, 2001).
Hollenberg, Morley D., et al., “Synergistic Actions of a Thrombin-Derived Synthetic Peptide and a Thrombin Receptor-Activating Peptide in Stimulating Fibroblast Mitogenesis,”J. Cell Physiol.169:491-496 (1996).
Backgrounder: “Chronic Wounds,” dated Sep. 2000, Human Genome Sciences, Rockville, MD [retrieved on Apr. 5, 2005]. Retrieved from the Internet: <URL: hgsi.com
ews/press/background—wounds.html>.
Davis Steve G.
Dinges Jason R.
Foley & Lardner LLP
Orthologic Corp.
Robinson Hope A
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