Methods of treating cancer with an antibody-drug conjugate

Details Methods of treating cancer with an antibody-drug conjugate Methods of treating cancer with an antibody-drug conjugate

2009-03-02

2011-10-11

Cordero Garcia, Marcela M (Department: 1654)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C424S179100, C424S178100

Reexamination Certificate

active

08034959

ABSTRACT:
The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.

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