Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-01-19
1994-11-08
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
424 54, 514901, 514902, 514928, A01N 4340, A61K 3144, A61K 722
Patent
active
053627377
ABSTRACT:
A method of treating aphthous ulcers and other mucocutaneous disorders is disclosed. The method comprises contacting the mucocutaneous disorder with a composition in the form of a paste, solution, gel, quick-disintegrating tablet, mouthwash, ointment, cream, powder, adhesive patch, aerosolized spray, lozenge, troche, dentifrice, or dental floss that contains an effective amount of an active compound of the formula: ##STR1## wherein R.sub.1 is hydrogen, alkyl, phenyl, carboxyl, hydroxyl, alkoxy, carboxyalkyl (i.e. esters), cyano, acylamino, or amino group which may be unsubstituted or substituted by up to two alkyl groups; m is 0, 1 or 2 and R.sub.2 is alkyl, alkenyl, alkoxy, halgoen, nitro, hydroxy, carboxyl, butadienylene (--CH.dbd.CH--CH.dbd.CH--) which forms a benzene ring with any adjacent carbon atoms, cyano, carboxyalkyl, trifluoromethyl, or amino group which may be unsubstituted or substituted by at least one alkyl; and R.sub.3 is carboxyl, cyano, arylalkoxycarbonyl, alkoxycarbonyl, or carboxamide which may be unsubstituted or substituted by at least one alkyl, and the salts thereof.
REFERENCES:
Remington's Pharmaceutical Sciences, Mack Publishing Co., 1975, pp. 1438-1439.
Accepted Dental Therapeutics; 38th edition, American Dental Association Chicago, 1979, pp. 257-284.
Handbook of Non prescription Drugs, American Pharmaceutical Association, Washington, D.C., 1977, pp. 249-263.
Khandwala Atul
Smith Charles G.
Vora Kakubhai R.
Chemex Pharmaceuticals, Inc.
Cook Rebecca
Richter Johann
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