Methods of treating alpha adrenergic mediated conditions

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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08063231

ABSTRACT:
Described herein are novel N-(2 and/or 3-substituted benzyl)-4,5-dihydro-1H-imidazol-2-amine derivatives processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals modulators of subtype α2Band/or α2Cadrenergic receptors.

REFERENCES:
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patent: WO 03/099289 (2003-12-01), None
patent: WO 2006/127426 (2006-11-01), None
“Prodrugs and Drug Delivery Systems,” which is a chapter in Richard B. Silverman, Organic Chemistry of Drug Design and Drug Action, 2d Ed., Elsevier Academic Press: Amsterdam, 2004, pp. 496-557.
David J. Hart et al (J. Org. Chem. 48: 289-294 (1983).
Messier et al., 1995, Pharmacol. Toxicol. 76, pp. 308-311.
Kim and Chung 1992, Pain 150, pp. 355-363.
Dixon, W.J., Ann. Rev. Pharmacol. Toxicol. 20:441-462 (1980).

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