Methods of treating allergies using TGF-β1 and allergens

Details Methods of treating allergies using TGF-β1 and allergens Methods of treating allergies using TGF-β1 and allergens

2006-02-28

2010-06-29

Woodward, Cherie M (Department: 1647)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C514S012200, C424S439000

Reexamination Certificate

active

07744895

ABSTRACT:
The invention provides an allergy prevention method or treatment method, diets and oral drugs enabling prevention/treatment of allergic symptoms without trouble such as systemic adverse reaction, immune deficiency and the like caused by transdermal/intravenous administration of TGF-β. The allergy prevention method or treatment method is to orally administer 100 μg/kg or more of transforming growth factor-beta (TGF-β) relative to a weight of an administration target body and thereby selectively suppress Th2 immune response, while with respect to the diets and oral drugs, the content is set to contain an effective amount of transforming growth factor-beta (TGF-β) therein.

REFERENCES:
patent: 5451411 (1995-09-01), Gombotz et al.
patent: 5461033 (1995-10-01), Donnet et al.
patent: 0527283 (1993-02-01), None
Laiho et al., Pediatr Res. Apr. 2003;53(4):642-7. Epub Jan. 29, 2003.
Janeway et al., Eds. Immunobiology: The Immune System Health and Disease. 5th Ed. Garland Publishing. New York. 2001, pp. 471-490.
Saito et al., Clin Exp Immunol. Oct. 1993;94(1):220-224, Abstract Only.
Ohtsuka et al., Curr Opin Gastroenterol. Nov. 2000;16(6):541-545.
Holt. Allergy. 1993;53(Suppl 46):16-19.
Okamoto et al., International Immunology. Apr. 18, 2005; 17(6):705-712.
Kalliomaki et al., J Allergy Clin Immunol. Dec. 1999; 104(6):1251-7.
Kulkami et al., PNAS USA. Jan. 15, 1993; 90(2):770-774.
Mersmann, Prog Food Nutr Sci., 1987 11(2):175-201.
Zemann et al., Allergy Clin Immunol. May 2003;111(5):1069-75.
Oddy et al. (,J Allergy Clin Immunol. Oct. 2003;112(4):723-8).
Oddy et al., (Pediatr Allergy Immunol. Jul. 9, 2009. pp. 1-13) [Epub ahead of print].
Meade et al., “Transforming Growth Factorβ1Inhibits Murine Immediate and Delayed Type Hypersensitivity” J immunology, vol. 149, 1992, pp. 521-528.
I. Penttila, “Effects of Transforming Growth Factor-Beta and Formula Feeding on Systemic Immune Responses to Dietary β-Lactoglobulin in Allergy-Prone Rats,” Pediatric Research, vol. 59, No. 5, 2006, pp. 650-655.
Coerper et al., “Recombinant Human Transforming Growth Factor Beta 3 Accelerates Gastric Ulcer Healing in Rats,” Scand J. Gastroenterol, vol. 32, 1997, pp. 985-990.
Hirshberg et al., “TGF-β3 in the Treatment of Pressure Ulcers: A Preliminary Report,” Advances in Skin & Wound Care, vol. 41, Mar./Apr. 2001, pp. 91-95.
Hawkes et al., “Variations in Transforming Growth Factor Beta in Human Milk are not Related to Levels in Plasma,” Cytokine, vol. 17, No. 4, Feb. 2002, pp. 182-186.
Derynck et al., “The Murine Transforming Growth Factor-β Precursor,” The Journal of Biological Chemistry, vol. 261, No. 10, Apr. 1986, pp. 4377-4379.
J. Massague, “The Transforming Growth Factor-β Family,” Annu. Rev. Cell Biol., vol. 6, 1990, pp. 597-641.
A. K. Abbas & A. H. Lichtman,Cellular and Molecular Immunology, Fifth Edition, 2003, Elsevier Science (USA), Ch. 19, pp. 432-435.
Okamoto et al., International Immunology vol. 17, No. 6, pp. 705-712, Jun. 2005; Epub Apr. 18, 2005.
Oddy, PhD et al., “TGF-B in human milk is associated with wheeze in infancy” J. Allergy and Clinical Immunology vol. 112, pp. 723-728 (Oct. 2003).
Saito et al., Clin Exp Immunol, “Transforming growth factor-beta (TGF-B) in human milk” vol. 94, pp. 220-224(1993).
Y. Chen et al, “Induction of oral tolerance to myelin basic protein in CD8-depleted mice: both CD4+ and CD8+ cells mediate active suppression”, J. Immunology, 1995, vol. 155, pp. 910-916.
J.J. Letterio, et al, “Regulation of Immune Responses by TGF-β”, Annu. Rev. Immunol., 1998, vol. 16, pp. 137-161.
Office Action dated Sep. 21, 2009 which issued in related Canadian Application No. 2,538,408.

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