Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2011-03-22
2011-03-22
Woodward, Cherie M (Department: 1647)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C128S898000, C424S422000, C424S085200, C604S502000
Reexamination Certificate
active
07910123
ABSTRACT:
Methods and apparatus of providing a subject with post-operative, sustained-release of a biological agent within a synovial joint is disclosed. These methods involve securing a depot containing the biological agent to a ligament, tendon, muscle within the joint to provide sustained-release of the agent while allowing for normal joint articulation. This methodology may be utilized to provide for sustained-release of a biological agent useful in treating various traumas and disorders of the joint. Such biological agents include antagonists of inflammation-related proteins, such as TNF-α, IL-1β, IL-6, IL-8, NF-κB, High Mobility Group Box 1 (HMG-B1), IL-2, IL-15 and steroidal and non-steroidal anti-inflammatories. Other biological agents include anti-inflammatory cytokines such as IL-10, IL-4, IL-13, and TGF-β. The biological agents also include osteogenic and cartilage producing growth factors such as, but not limited to, BMP-2, BMP-4, BMP-6, BMP-7, BMP-8, and MIA CD-RAP. Finally, the biological agents include siRNA and/or therapeutic antibodies.
REFERENCES:
patent: 2568207 (1951-09-01), Spicher
patent: 4353370 (1982-10-01), Evans
patent: 4532926 (1985-08-01), O'Holla
patent: 4534350 (1985-08-01), Golden et al.
patent: 5378475 (1995-01-01), Smith et al.
patent: 5423858 (1995-06-01), Bolanos et al.
patent: 5545180 (1996-08-01), Le et al.
patent: 5773019 (1998-06-01), Ashton et al.
patent: 6001386 (1999-12-01), Ashton et al.
patent: 6083522 (2000-07-01), Chu et al.
patent: 6656182 (2003-12-01), Hayhurst
patent: 6916483 (2005-07-01), Ralph et al.
patent: 6936270 (2005-08-01), Watson et al.
patent: 2001/0010005 (2001-07-01), Kammerer et al.
patent: 2002/0169162 (2002-11-01), Smith et al.
patent: 2003/0195527 (2003-10-01), Helmus
patent: 2004/0115236 (2004-06-01), Chan et al.
patent: 2005/0025765 (2005-02-01), DiMauro et al.
patent: 2005/0031665 (2005-02-01), Watson et al.
patent: 2005/0152949 (2005-07-01), Hotchkiss et al.
patent: 2005/0260247 (2005-11-01), Ralph et al.
patent: 2006/0195139 (2006-08-01), Gertner
patent: 2006/0246103 (2006-11-01), Ralph et al.
patent: 2008/0228193 (2008-09-01), Matityahu
patent: WO99/24061 (1999-05-01), None
patent: WO02/28366 (2002-04-01), None
patent: 2004012627 (2004-02-01), None
patent: WO2006/028939 (2006-03-01), None
patent: 2007121288 (2007-10-01), None
patent: 2008112592 (2008-09-01), None
Image—Google.com—lipscombclinic.com—knee anatomy publication (URL on image), last accessed Feb. 19, 2009.
Steadman's Medical Dictionary, 27th Edition, 2000, definition of Cartilage.
Steadman's Medical Dictionary, 27th Edition, 2000, definition of Ligament.
Eaton, et al., (Med Health R.I. Jul. 2004;87(7):201-4, Abstract Only).
International Search Report in PCT/US2008/075435, filed Sep. 5, 2008, 9 pages.
Warsaw Orthopedic
Woodward Cherie M
LandOfFree
Methods of treating a trauma or disorder of the knee joint... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of treating a trauma or disorder of the knee joint..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of treating a trauma or disorder of the knee joint... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2644208