Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Heavy metal or compound thereof
Patent
1995-06-02
1998-07-07
Ziska, Suzanne E.
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Heavy metal or compound thereof
424 91, 424600, 514 1, 514 2, 514 44, 4351723, C12N 1500, A61K 4900, A61K 3300, A61K 3170
Patent
active
057765022
ABSTRACT:
The present invention provides a method of transcriptionally modulating the expression of a gene of interest, the expression of which is associated with a defined physiological or pathological effect within a multicellular organism. The method comprises contacting a cell which is capable of expressing the gene with an amount of a molecule effective to transcriptionally modulate expression of the gene and thereby affect the level of the protein encoded by the gene which is expressed by the cell. Molecules useful in the practice of the invention are characterized as follows (a) do not naturally occur in the cell, (b) specifically transcriptionally modulate expression of the gene of interest, and (c) bind to DNA or RNA or bind to a protein through a domain of such protein which is not a ligand binding domain of a receptor which naturally occurs in the cell, the binding of a ligand to which ligand binding domain is normally associated with the defined physiological or pathological effect.
REFERENCES:
patent: 4699978 (1987-10-01), Barton
patent: 4721669 (1988-01-01), Barton
patent: 5087438 (1992-02-01), Gordon et al.
patent: 5540931 (1996-07-01), Hewitt et al.
Foulkes J. Gordon
Franco Robert
Leichtfried Franz
Pieler Christian
Stephenson John R.
Oncogene Science, Inc.
White John P.
Ziska Suzanne E.
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