Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-05
2000-12-26
Carlson, Karen Cochrane
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435440, 435455, 435471, 435475, 435325, 4352523, 43525233, 43525411, 435 4, 435 691, 4353201, 536 241, C12Q 168, C12N 1509
Patent
active
061657123
ABSTRACT:
The present invention provides a method of transcriptionally modulating the expression of a gene encoding a protein of interest, the expression of which gene is associated with the production in cell culture of a protein encoded by the gene, which comprises contacting a cell, which is capable of expressing the gene, with an amount of a molecule effective to transcriptionally modulate expression of the gene and thereby affect the level of the protein encoded by the gene which is expressed by the cell in culture, which molecule (a) directly transcriptionally modulates expression of the gene.
REFERENCES:
patent: 4535058 (1985-08-01), Weinberg et al.
patent: 4601978 (1986-07-01), Karin
patent: 4699877 (1987-10-01), Cline et al.
patent: 4736866 (1988-04-01), Leder et al.
patent: 4738922 (1988-04-01), Haseltine et al.
patent: 4740461 (1988-04-01), Kaufman
patent: 4740463 (1988-04-01), Weinberg et al.
patent: 4761367 (1988-08-01), Edgell et al.
patent: 4761371 (1988-08-01), Bell et al.
patent: 4774182 (1988-09-01), Szybalski
patent: 4806463 (1989-02-01), Goodchild et al.
patent: 4827079 (1989-05-01), Evans et al.
patent: 4861709 (1989-08-01), Ulitzer et al.
patent: 4885238 (1989-12-01), Reddel et al.
patent: 4935363 (1990-06-01), Brown et al.
patent: 4981783 (1991-01-01), Augenlicht
patent: 4981790 (1991-01-01), Haseltine et al.
patent: 5070012 (1991-12-01), Nolan et al.
patent: 5071773 (1991-12-01), Evans et al.
patent: 5075229 (1991-12-01), Hanson et al.
patent: 5262300 (1993-11-01), Evans et al.
patent: 5776502 (1998-07-01), Foulkes et al.
S.T. Crooke. "Basic Principles of Antisense Therapeutics". in Antisense Research and Application. New York :Springer-Verlag. pp. 1-50, 1998.
Ringold et al. "Glucocorticoid stimulated accumulation of mouse mammary tumor virus RNA: Increased rate of synthesis of viral RNA." Proc. Nat. Acad. Sci., USA 74 (7):2879-2883, Jul. 1977.
Ritzi et al. "Glucocorticoids stimulate the release of a viral tumor marker (MMTV gp52) while inhibiting tumor cell growth" J. steroid Biochem. 32(4):499-505, Apr. 1989.
Ucker et al. "Glucocorticoids and chromosomal position modulate murine mammary tumor virus transcription by affecting efficiency of promoter utilization." Mol. Cell. Biology 3(4): 551-561, Apr. 1983.
Cripe et al.. Transcriptional regulation of the human papillomavirus-16- E6-E7 promoter by a keratinocyte dependent enhancer and by viral E2 transactivator and repressor gene products:implications for cervical carcinogenesis. EMBO J. 6(12): 3745-3753, 1987.
Davis et al. Immediate-early gene region of human cytomegalovirus trans-activates the promoter of human immunodeficiency virus. Proc. Nat. Acad. Sci., USA, 84(23): 8642-8646, Dec. 1987.
Mosca et al. Activation of human immunodeficiency virus by herpesvirus infection: Identification of a region within the long terminal repeat that responds to a transacting factor encoded by herpes simplex virus 1. Proc. Nat. Acad. Sci., USA 84: 7408-7, Nov. 1987.
Schneider et al. Mutational analysis of the adenovirus E1a gene: the role of transcriptional regulation in transformation. EMBO J. 6(7): 2053-2060, 1987.
Paterson et al. Mutational dissection of the HSV-1 immediate early protein Vmw175 involved in transcriptoinal transactivation and repression. Virology 166 (1): 186-196, 1988.
Jordan et al. The L protein of a VSV mutant isolated from a persistent infection is responsible for viral interference and dominance over the wild type. Virology 169(1):137-141, Mar. 1989.
Lambert et al. A transciptional repressor encoded by BPV-1 shares a common carboxyterminal domain with the E2 transactivator. Cell 50(1):69-78, Jul. 3, 1987.
Uhlmann et al. Antisense Oligonucleotides: A New Therapeutic Principle, In Chemical Reviews, 90(4):544-584, 1990.
Andersen, R. et al. (1990) "Metal-Dependent Binding of A Nuclear Factor to the Rat Metallothionein-I Promoter," Nucleic Acids Research 18 (20): 6049-6055.
Angel, P. et al., (1987 A) "Phorbol Ester-Inducible Genes Contain A Common Cis Element Recognized by An TPA-Modulated Trans-Acting Factor," Cell 49: 729-739.
Angel, P. et al., (1987 B) "12-O-Tetradecanoyl-Phorbol-13-Acetate Induction of the Human Collagenase Gene Is Mediated by an Inducible Enhancer Element Located in the 5'-Flanking Region," Molecular and Cellular Biology, 7: 2256-2266.
Bickel, M. et al., (1988) "Granulocyte-Macrophage Colony-Stimulating Factor Regulation in Murine T Cells and Its Relation to Cyclosporin A," Ex. Hematol. 16: 691-695.
Blumberg, P., (1988) "Protein Kinase C as the Receptor for the Phorbol Ester Tumor Promoters: Sixth Rhoads Memorial Award Lecture," Cancer Research 48: 1-8.
Brasier, A. et al., (1989) "Optimized Use of the Firefly Luciferase Assay as a Reporter Gene in Mammalian Cell Lines," BioTechniques 7 (10): 1116-1122.
Brenner C. et al., (1989) "Message Amplification Phenotyping (Mapping): A Technique to Simultaneously Measure Multiple mRNAs from Small Numbers of Cells," BioTechniques 7 (10): 1096-1103.
Cao, T., (1989) "A Simple and Inexpensive System to Amplify DNA by PCR," BioTechniques 7 (6): 566-567.
Cohen, P. and Foulkes, J.G. eds., (1991) The Hormonal Control of Gene Transcription, 92-93, 235-236.
Comb, M. et al. (1986) "A Cyclic AMP- and Phorbol Ester-Inducible DNA Element," Nature 323: 353-356.
Connelly, C. et al., (1989) "The Role of Transgenic Animals in the Analysis of Various Biological Aspects of Normal and Pathologic States," Experimental Cell Research 183: 257-276.
Cybulsky, M. et al., (1991) "Gene Structure, Chromosomal Location, and Basis for Alternative mRNA Splicing of the Human VCAM1 Gene," Proc. Natl. Acad. Sci. USA 88: 7859-7863.
Das. H. et al., (1988) "Cell Type-Specific Expression of the Human ApoB Gene Is Controlled by Two Cis-Acting Regulatory Regions," Journal of Biological Chemistry 263 (23): 11452-11458.
de Wet et al., (1987) "Firefly Luciferase Gene Structure and Expression in Mammalian Cells," Molecular and Cellular Biology 7 (2): 725-737.
Emmel. E. et al., (1989) "Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation," Science 246: 1617-1620.
Engebrecht. J. et al., (1985) "Measuring Gene Expression with Light." Science 227: 1345-1347.
Gunter. K. et al., (1989) "Cyclosporin A-Mediated Inhibition of Mitogen-Induced Gene Transcription Is Specific for the Mitogenic Stimulus and Cell Type," Journal of Immunology 142: 3286-3291.
Higuchi, K. et al., (1988) "Tissue-Specific Expression of Apolipoprotein A-I (Apo I) Is Regulated by the 5'-Flanking Region of the Human ApoA-I Gene," Journal of Biological Chemistry 263 (34): 18530-18536.
Holbrook, N. et al., (1984) "T-Cell Growth Factor: Complete Nucleotide Sequence of Organization of the Gene in Normal and Malignant Cells," Proc. Natl. Acad. Sci. USA 81: 1634-1638.
Hsu, M. et al., (1991) "Inhibition of HIV Replication in Acute and Chronic Infections in Vitro by a Tat Antagonist," Science, 254: 1799-1802.
Ishii, S. et al., (1985) "Characterization and Sequence of the Promoter Region of the Human Epidermal Growth Factor Receptor Gene," Proc. Natl. Acad. Sci. USA 82: 4920-4924.
Kaushansky, K. et al., (1985) "Genomic Cloning, Characterization, Multilineage Growth-Promoting Activity of Human Granulocyte-Macrophage Colony-Stimulating Factor," Proc. Natl. Acad. Sci. USA 83: 3101-3105.
Kawasaki, E. et al., (1985) "Molecular Cloning of a Complementary DNA Encoding Human Macrophage-Specific Colony-Stimulating Factor (CSF-1)," Science 230: 291-296.
Knott, T. et al., (1986) "Complete Protein Sequence and Identification of Structural Domains of Human Apolipoprotein B," Nature 323: 734-738.
Kronke, M. et al., (1984) "Cyclosporin A Inhibits T-Cell Growth Factor Gene Expression at the Level of mRNA Transcription," Proc. Natl. Acad. Sci. USA 81: 5214-5218.
Ladner, M. et al., (1987) "Human CSF-1: Gene Structure and Alternative splicing of mRNA Precursors," The EMBO Journal 6 (9): 2693-2698.
Lamb, P. et al., (1986) "Characterization of the Human p53 Gene," Molecular and Cellular Biology 6 (5): 1379-1385.
Lee, M-T. et al., (1990) "Differential Expression of M-CSF, G-CSF, and GM-CSF by Human Monocytes," Biol. Abst
Case Casey C.
Foulkes J. Gordon
Leichtfried Franz E.
Pieler Christian
Stephenson John R.
Bugaisky Gabriel E.
Carlson Karen Cochrane
OSI Pharmaceuticals, Inc.
White John P.
LandOfFree
Methods of transcriptionally modulating expression of viral gene does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of transcriptionally modulating expression of viral gene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of transcriptionally modulating expression of viral gene will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-993071